Prospective new biologic therapies for psoriasis and psoriatic arthritis. Mortel MR, Emer J. J Drugs Dermatol. 2010 Aug;9(8):947-58. In the very young and trendy world of the “biologics” in the treatment arsenal of Psoriasis and Psoriastic arthritis, agents with different molecular targets have come. Some like Etanercept and Infliximab are thriving and some because of…
Cosmetic Pigmentary Concerns in Singaporeans (For Professionals) differences between Asian vs European skin (a/e): avoids sunlight / loves sunlight skin type III to VI / skin type I to III post inflammatory hyperpigmentation +++ / + or – solar induced changes + / +++ Ageing: wrinkling + / +++ pigmentation +++ / + Telangiectasia +…
Skin Diseases Described By Japanese Dermatologists (For Professionals) A few conditions described (non-exhaustive): Ota – nevus of Ota (1939), nevus fusco-coerelus ophtalmomaxillaris. Ota was also a writer Ofuji eosinophilic pustular folliculitis (1970) mostly affects individuals between 20 and 30. Eosinophilic puistules on histology with blood eosinophilia 3 types: classic, immmunosuppressive (HIV), infancy-associated. Treatments: indomethacin (most…
Dermatologic Conditions in South-East Asia (For Professionals) There are only 7 derms per million people in India. Mostly in metroppolitan areas which means that in rural areas, this can go down to one dermatologist for a million people. Insurance only covers inpatient treatment, not chronic disorders. For 99% of the population, IVIG, biologics and ciclosporine…
Role Of The Dioxin Receptors (Aryl Hydrocarbon Receptors (AhR)) In The Induction of The Expression of The Matrix Metalloproteinase (MMP) – 1 Enzyme By Tobacco Smoke Extracts (For Professionals) Two types of aging: intrinsic aging extrinsic aging: ultraviolet and tobacco smoking odds ratios for wrinkles in patients with risk factors versus no risk factor individuals…
Role Of The Microfibrills of Fibrillin In Aging (Ageing) And Photoaging (Photoageing) (Sun-induced Ageing) (For Professionals) Presentation of fibrillin is an extracellular protein is responsible as scafolding for deposition elastic fibres exists as fibrillin f1 and 2 encoded by FBN1 and 2 encoding Marfan syndrome Functions of fibrillin: strengthens elastic fibres and enables transmission of…
Solar Lentigo (For Professionals) Epidemiology Occurs mostly in Caucasians phototypes1,2 and 3 Affects worldwide 90% of humans over 70 of age. This amounts today to 600 million aged 65 and over, this will be 2 billion individuals in 2050 Psychological impact it is a marker of aging and is visible as it occurs mostly on…
What’s New In The Pathogenesis And Prevention Of Extrinsic Aging (Ageing) (Photoaging) (For Professionals) Photoaging (Extrinsic Aging, solar elastosis) Skin Aging can be Understood by considering two concepts Cumulative acute stress through chronic mechanisms: three stages degeneration of macromolecules Altered cell function Modified Structure and function of organs Mt (mitochondrial) DNA mutation: increased oxidative stress…
Laser Hair Removal – 2010 Effects of the 810-nm diode laser on hair and on the biophysical properties of skin. Ilknur T, Biçak MÜ, Eker P, Ellidokuz H, Özkan S. J Cosmet Laser Ther. 2010 Dec;12(6):269-75. Evaluation of the vacuum-assisted handpiece compared with the sapphire-cooled handpiece of the 800-nm diode laser system for the use…
[Polychromatic pulsed lamp]. Le Pillouer-Prost A, Cartier H, Raimbault C. Ann Dermatol Venereol. 2009 Oct;136 Suppl 6:S335-50. French. [Laser hair removal]. Michaud T, Tack B. Ann Dermatol Venereol. 2009 Oct;136 Suppl 6:S330-4. French. Treatment of laser complications. Alster TS, Khoury RR. Facial Plast Surg. 2009 Dec;25(5):316-23. Intense pulsed light: what works, what’s new, what’s next.…
