Rhododendrol (Rhododenol, RD) created a big problem in Japan, when 14000 induced cases of vitiligo-like lesions were reported. It is known that Rhodoendol is cytoxic against melanocytes in a Tyrosinase dependent way cytotoxicity The authors suggest a new mouse model for the study of this effect: hk14-scf/HRM Tg Mice become albino (fully depigmented) through suppression…
The phenolic compound phloretin: is a member of dihydrochalcones is found in apples and apple juice Phloretin 3,3 disulfonate (P33D) is obtained after its sulfonation with sulfuric acid Pure concentrated Phloretin sodium sulfonate was added to Human Cell cultures which were irradiated with UVB 20 mJ/cm2 Results show that reduced amounts of P33D were found…
In early 20th century Europe, it was considered a mark of “low-class”, as it was assimilated with outdoor professional activities. It is quite fashionable to tan in Western societies (Europe and North America), but is definitely not fashionable in Asia. Tanning is a process induced by ultraviolet light and is a protective mechanism to shield…
The excimer laser is a 308nm device used in the treatment of localized lesions of psoriasis and vitiligo. In this study done on mice (“dry skin model”), atopic dermatitis (AD) was induced with application of “dermatphagoides farina body” ointment in shaved area twice a week for 3 weeks ANTIHYPERINNERVATION. Results after one excimer session show:…
Atopic Dermatitis (AD), beyond filaggrin mutations is better understood, but still remains (at the time of publication) full of gaps. pH alterations in AD are a matter of debate, but they do have an effect on its symptoms (itching) and appearance. This study shows molecular as well as physical alterations in AD. KLK5 can catalyze…
Alopecia Areata (AA) is an inflammatory cause of non-scarring alopecia which carries a lifetime risk 1.7% Treatment options now available include, topical and intralesional steroids, Diphencyprone (DCP), oral steroids (in pulse dose) Genetics is poorly understood: innate and adaptive immunity The cause of the infiltrate of T cells at the base of hair follicles is…
The nuclear membrane separates the nucleus from the cytosol (cytoplasm) several proteins shape are part of its different layers. its role is to maintain mRNA and protein trafficking Lamin A and C are 2 of the main proteins. Its coding gene LMNA is mutated in the premature aging syndrome called the Hutchinson-Gilford progeria syndrome Progerin…
Royal-jelly is a yellowish material secreted from the hypopharyngeal and mandibular glands of worker honeybees. It has been shown to have a protective effect on dry skin (epidermal hydration) In this study, dietary (oral) supplementation was given: Total of 47 subjects (mean age: 41.3 years old +/- 6.2) capsules of 520mg taken once a day…
Cartilage oligomeric metric protein is part of the “non-collagen” proteins of the extracellular matrix and interacts with collagen I via fibril associated fibrils XII and XIV was previously only found in cartilage In fibrotic skin such as in localized scleroderma (morphea) wound tissue and exudates of patients with venous ulcers and in the stroma of…
When looking at psoriasis lesions, numerous T cells are present. In 1979, cyclosporine was shown to act on psoriasis as a T cell suppressor. Nevertheless, at that time but it was also shown to have an antiproliferative action on keratinocytes. Result: the biological action (cytokine inhibition) was overlooked. T cells are stimulated by antigen presenting…
