A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Gubelin Harcha W, Barboza Martínez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, Barnes A, Ferron-Brady G, Chetty D. J Am Acad Dermatol. 2014 Mar;70(3):489-498.e3.…
In this presentation, the presenter takes us to the origins of humanity end explores the great human migrations in the last 2000 years – the genetic variations responsible for the evolution of skin colour are presented to us. The beginning is in Africa; Darwin quotes that “the giant ape is the cousin of mankind”. The…
A role of placental growth factor in hair growth. Yoon SY, Yoon JS, Jo SJ, Shin CY, Shin JY, Kim JI, Kwon O, Kim KH. J Dermatol Sci. 2014 May;74(2):125-34. doi: 10.1016/j.jdermsci.2014.01.011. Epub 2014 Feb 6. Hair growth is a process which requires the presence of a hair follicle and a functional dermal papilla (DP).…
Demodicosis is a disease in itself due to the presence of the mite Demodex folliculorum first classied as such in 1842 by the German dermatologist Carl Gustav Theodor Simon. It is easily confused with Rosacea (Acne Rosacea) because the latter, although considered to be associated with the presence of the mite, is controversial and an…
Propionibacterium acnes: an update on its role in the pathogenesis of acne. Beylot C, Auffret N, Poli F, Claudel JP, Leccia MT, Del Giudice P, Dreno B. J Eur Acad Dermatol Venereol. 2014 Mar;28(3):271-8. doi: 10.1111/jdv.12224. Epub 2013 Aug 1. P. acnes is a bacteria whic has a strong proinflammatory activity and targets molecules involved in…
Il-17 targeting is the new trend in the biologic systemic treatment of psoriasis. Ustekinumab (Stelara) is the main one used today in that sense. Secukinumab: is a fully anti-interleukin-17A monoclonal antibody is (at the time of publishing this article) the latest Il-17A drug to have exited phase III trials. The results out of two studies…
Some of the infections which affect the body can manifest itself with some skin changes. This is what happens in Lyme disease (also called Borreliosis). Lyme disease is a bacterial illness caused by a spiral shaped bacteria (spirochete) named Borrelia burgdorferi. These are bacteria which are often found in deer. What happens is that the…
Lichen Planopilaris Treated With a Peroxisome Proliferator—Activated Receptor γ Agonist Paradi Mirmirani, MD and Pratima Karnik, PhD Arch Dermatol. 2009 December; 145(12): 1363–1366. Lichen planopilaris is a form of scarring alopecia and beyond dignosis and steroid treatment, little is available. This article shows an alternative therapeutic modality. The mode of action is through agnosit action…
If you are sensitive to sunlight, you may have a condition known as photosensitivity. Photosensitivity is often defined as the amount to which a person reacts upon receiving light. There are many conditions which can give rise to sensitivity of the skin to a light source. It is said that people with particular skin types…
Leprosy (Hansen’s disease) is an often ignored skin disease and this infectious disease can sometimes affect the nervous system. Non-specific nail changes can be found in Leprosy. The authors sought to study nail changes in leprosy: In this study cases of Hansen’s were collected from August 2011 to April 2012 (exclusion congenital nail deformities, fungal…
