Long-lasting Hair Removal: Is it Possible ? (For Professionals) A lot of time and financial resources are spent by the patients for hair removal. It is often believed by the public that hair removal can be complete aften multiple treatment sessions. However this is wrong for many reasons: different lasers achieve different long term results…
DetailsCapsaicin used topically is used in the treatment of pain following for example shingles = post herpetic neuralgia. In the following study, capsaicin receptors appear to be reduced Capsaicin receptor is also known as TRPV1 32 Patients with psoriasis (lesional) were compared with 20 with normal skin Results TRPV1 was found by RTPCR (polymerase chain…
DetailsPathogenesis of melasma (chloasma) (pregnancy mask) remains unknown. Treatment which is effective on the epidermal component of the pigmentation acts by the following mechnisms: inhibition of melanin synthesis blockage of melanosome transker from melanocytes and keratinocytes (niacinamide). Solar eviction and photoprotection are a crucial element in the treatments. The gold standard in the treatment of…
DetailsAcupuncture is known as a treatment of chronic symptoms such as pain, joint pain and the like and the following study shows interesting results in the treatment of itch (pruritus). In this in vivo study, *90 mice were treated: with a substance substance causing itch (in 30 mice) (compound 48/80) (subcutaneous injection behind the…
DetailsHydroquinone is the gold standard in the treatment of hyperpigmentary disorders but there are 3. things to bear in mind: -a concentration of 4% or more is needed to be effective. -because of a higher concecntration, side effects such as exogenous ochronosis are a risk. Because of a lack of evidence pertaining to long term…
DetailsThe next world congress on skin pigmentation research will take place in 2014 in Singapore. Below is the introduction from the organizer: On behalf of the Asian Society for Pigment Cell Research (ASPCR) and Dermatological Society of Singapore (DSS), it is our pleasure to officially introduce the 22nd International Pigment Cell Conference (IPCC) to you,…
DetailsVitiligo is characterized by the functional loss of melanocytes which induces the well delineated depigmented characteristic lesions. Anomalies have been detected in: melanocytes (mitochondria…) keratinocytes (altered oxydation status in the mitochondria, vaculolization…) dermis (high level of tenascin expression which explains defective adhesion of the melanocytes) The authors have found similar defects in fibroblast cells in…
DetailsThe authors shoe that on computer models, validamycin A induces changes in the protein structure of tyrosinase. Tyrosinase is an enyyme involved in the early phases of melanin synthesis. Hore exactly based on targetted hydroxyl group number: HIS85, HIS244, GLU256, HIS259, and ASN260 of tyrosinase interacted with validamycin A. Comment: the conceptual role of validomycin…
DetailsShingles is due to the activation of the herpes zostervirus (HZV) following its reactivation from doral ganglia following chicken pox. It is usually self-limited but after 60 there is a much higher incidence of pain following shingles (post-herpetic neuralgia). The pain can last from months to years afterwards. Incidence of shingles and post herpetic…
DetailsMattek is a company which produces artificial skin models and the authors show application for pigmentary disorders models such as melasma (chloasma, pregnancy mask) and postinflammatory hyperpigmentation. In the study the authors used MelanoDermTM, which is a three-dimensional tissue culture model of human epidermis that contains normal human melanocytes (NHM) and keratinocytes (NHK). The origin of donors (African…
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