Systematic review of oral treatments for seborrheic dermatitis. Gupta AK, Richardson M, Paquet M. J Eur Acad Dermatol Venereol. 2014 Jan;28(1):16-26. doi: 10.1111/jdv.12197. Epub 2013 Jun 26. Seborrheic dermatitis (SD) is a common inflammatory disorder which affects: the scalp where it creates flaking of the skin or what is known as common dandruff (Pityriasis capitis).…
DetailsOutline: Acne Vulgaris – New Insights From The Bench To The Clinic + overstimation of the risks of oral isotretinoin Recent advances in acne research have allowed a better understanding of the pathogenesis and etiological factors associated with acne: sebum overproduction by sebaceous glands is influenced by: dihydrotestosterone (DHT) Insulin-like Growth Factor (IGF)-1 PPAR ligands…
DetailsSerum granulysin as a possible key marker of the activity of alopecia areata. Ono S, Otsuka A, Yamamoto Y, Kataoka TR, Koyanagi I, Miyachi Y, Kabashima K. J Dermatol Sci. 2014 Jan;73(1):74-9. doi: 10.1016/j.jdermsci.2013.08.009. Epub 2013 Sep 2. Alopecia areata (AA) is an auto-immune inflammatory dermatosis of the scalp resulting in non-scarring rounded patches of…
DetailsThe matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. Egbert M1, Ruetze M2, Sattler M1, Wenck H1, Gallinat S1, Lucius R3, Weise JM4. J Dermatol Sci. 2014 Jan;73(1):40-8. doi: 10.1016/j.jdermsci.2013.08.010. Epub 2013 Sep 3. Skin aging can be seen: on the epidermis by changes in texture and color. in…
DetailsSubtypes 1, 2 and 3 have different upregulated genes. However there is a 20-30% overlap in the similarity of the genes being upregulated. Rosacea can be divided into two distinct forms; In the typical form, rosacea can progress from subtypes 1, 2 and 3. But not necessarily as we know that there are genetic similarities,…
DetailsAmerican Academy of Dermatology (AAD) Annual Meeting San Diego, CA, USA 8 – 12 March www.aad.org
Chronic Urticaria (For Professionals) Chronic urticaria is a clinical sign of wheals appearing for more than 6 weeks. Numerous causes are identified and sometimes and auto-immune condition is found. If no cause is found which ranges from 25% to 75% of cases, autologous serum skin testing can be done, followed by dosing of anti-FCeRI antibodies…
DetailsMetformin in dermatology: an overview. Badr D, Kurban M, Abbas O. J Eur Acad Dermatol Venereol. 2013 Nov;27(11):1329-35. doi: 10.1111/jdv.12116. Epub 2013 Feb 26. Metformin is an oral hypoglycaemic agent. It acts by decreasing hepatic glucose output and increases the glucose utilization by muscles and adipocytes (increase in sensitivity to insulin) It also has a…
DetailsSildenafil which is more commonly known by its brand name ©Viagra is a phosphodiesterase inhibitor and therefore acts as a vasodilator In this prospective study 7 female patients with systemic sclerosis were enrolled: all of them had digital ulcerations and Raynaud’s phenomenon treatment with calcium channel inhibitors was ineffective dosage of sildenafil was 50-75mg per…
DetailsEndogenous ochronosis (also called alcaptonuria) is a rare autosomal regressive disorder where there is enzymatic deficiency of homongentisic acid oxydase (AHG). This results in accumulation of AHG which is oxydized and polymerized in a substance close to melanin called benzoquinone acetic acid (ABQA). Its accumulation in the skin results in the clinical pigmentation. The…
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