George Herbert Walker Bush (b.1924), a Republican, served two terms under President of the United States. Once playing a round of golf in Summer 2002, he has caught on photograph with the following lesions. In fact, the lesions are precancerous growths called actinic keratoses. 5-fluorouracil (known as Efudex in the United States) is one treatment…
DetailsBob Marley (; 1945-1981) was a Jamaican singer who participated importantly in the development Reggae and was part part of the cultural “Rastafari” movement He was a big soccer enthusiast and in summer of 1976 he traumatized his right toenail. It was diagnosed as a wound lesion and slowly appeared to be healing. However, such…
DetailsOtezla (apremilast): systemic (oral) “small molecule” used in the treatment of psoriasis Note that the list is updated regularly as all pharmaceutical companies and products are not included. This is simply a guide to medications which are known to the authors of the website. Full-indications may not be included and side effects are not mentioned.…
DetailsCosentyx ® (secukinumab): biologic medical used in the treatment of psoriasis Lamisil ® (terbinafine): topical and systemic substance used in the treatment of fungal infections Note that the list is updated regularly as all pharmaceutical companies and products are not included. This is simply a guide to medications which are known to the authors of…
DetailsIntroduction This article provides new potential molecular mechanisms providing interesting insights in the understanding of psoriasis. Cytokines and genetic findings constitute part of the findings in psoriasis and these have led to the development of the biologics. The following study talks about MicroRNAs miRNA are RNAs not translated into proteins: their size is between 19-25…
DetailsOmalizumab (Xolair): recombinant humanized monoclonal antibody that binds to the free Immunoglobin IgE (produced byB lymphocytes), more specifically on the C3 domain of the IgE heavy chain complete, it block free IgE. Unlike ordinary anti-IgE antibodies, it does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the…
DetailsExisting TNF-inhbitors: Adalimumab (Abbott) Infliximab (Janssen Bitotech and other biosimilars (generics) Etanercept (Amgen) Certolizumab (UCB) Il-17 antibodies Secukinumab (Cosentyx, Novartis): dosage: injected 300mg at weeks 0, 1, 2, 3, and 4 then 300mg or 150mg every 4 weeks, the doctor decides ! The price is the same for both doses ! Works in 3 weeks…
DetailsAvailable “small molecules”: Apremilast (Otezla) inhibits phosphodiesterase 4 (PDE4) exhibits anti-inflammatory properties apart from PDE4 action, its complete effects are not fully known but it is known (at the time of writing) that it modulates inflammation by reducing TNF-alpha, Il-2, IFN-gamma, leukotrienes and NO synthases. The effect appears to act through increased intracellular cAMP accumulation…
DetailsSevere rhabdomyolysis with Isotretinoin Therapy for Acne (Poster) Philips D et al. AAD 2015 Annual Meeting, San Francisco CA – United States Isotretinoin is an oral vitamin D derivative most commonly used in the treatment of acne. Common side effects include skin and mucosal dryness, lipid elevations and elevated liver enzymes. According to some, the…
DetailsAcitretin: is a metabolite of etretinate is FDA-approved for use in psoriasis is less lipophilic than the former and fat storage (half life 120 days): It is highly highly toxic to embryos during pregnancies (teratogenic) and contraception in women must be used for at least 2 years (come say 3 three years) no safe dosage:…
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