In 1905 , the cause of syphilis was found by two German dermatologists: a spirochaete bacteria called Treponema Pallidum When presented at a meeting of the Berlin medical society, the president, Prof Ernst Von Bergmann, cut him short with words he no doubt later regretted. “This terminates the discussion – until the next cause of…
DetailsEpidemiology of Hidradenitis suppurativa (HS) also called Acne Inversa (Jemec) -Prevalence is anywhere between 0.0033% (genetic hypothesis) to 4% (self reporting in nurses) -In a big study in immigrants comparing with Spanish citizens, prevalence of HS was found to reach 0.2% up to 0.9% in Spanish citizens. prevalence is anywhere between 0.0033% (genetic hypothesis) to…
DetailsErythrodermic psoriasis (EP) is a generalized, inflammatory erythematous dermatosis, with or without exfoliation lasting for at least 3 months involving 75% or more of the body surface Methods: In this retrospective study PASI evaluation was done at 4, 16 and 28 weeks of treatment 22 patients dosage of 45mg in 16 patients dosage of 90mg…
DetailsBrodalumab (KHK4827, also known as AMG827) is a monoclonal antibody that binds to human IL-17RA and blocks the biological activities of IL-17A, 17F, 17A/F and IL-17E It has been shown to improve plaque psoriasis and psoriatic arthritis in 12 weeks. Goal: efficacy of KHK4827 for nail nail and scalp psoriasis in Japanese patients with moderate…
DetailsLipofucsin is the intracellular aggregate of oxidized proteins and lipids. It is a marker of autophagy and is stainable on immunochemistry with Sudan Black B (SBB) Ultraviolet A (UVA) damage induces DNA damage, oxidation of proteins and lipids, autophagy and subsequently apoptosis (provided exposure is long enough) In this study human cultures of fibroblasts were…
DetailsIntroduction: Palmoplantar psoriasis presents as sterile pustules with hyperkeratosis, erythema, scaling and fissuring on the palms and soles Treatment is challenging. topicals don’t really work and acitretin is not always effective. Methodology: prospective study 9 patients, mean age 48 years old ustekinumab administered subcutaneously at weeks 0,4 and then every 12 weeks evaluation with PPPASI…
DetailsPRP is an autologous platelet concentrate in a small volume of plasma obtained from high speed centrifugation of the patient blood sample Methods 26 patients with vitiligo (type and location not specified) Intradermal intralesional PRP injection was done every 2 weeks until a response was observed or improvement was seenscoring with the Vitiligo European task…
DetailsAdalimumab showed a slightly higher reduction in PASI after 1 year, however it proved an equivalent efficacy to Etanercept after an extensive follow-up (up to 5 years) Contrarily to etanercept, adalimumab patients showed a progressive improvement with DLQI (84 to 77) For both groups, sustained response (PASI75 maintenance of results 60 months after initiation of…
DetailsInfliximab is an anti-TNF biologic It is used in the treatment of rheumatoid arthritis, psoriasis and inflammatory bowel disease A case report from Spain: 32 year old female known for Crohn’s disease no response to mesalazine and systemic corticosteroids was subsequently put on infliximab at a dosage 5mg/kg for a duration of 10 years she…
DetailsIn this Indian study, protein samples of Mycobacterium Tuberculosis (similar to the one used in the Mantoux screening test) were used: PPD – purified derivative of M.Tuberculosis 10IU PPD 0,1ml indication: facial and palmoplantar warts or more than 15 (no mention of genital warts) 2.5 IU (or TU: Tuberculin Units) on left forearm 2.5 IU…
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