Effect of tranexamic acid on melasma: a clinical trial with histological evaluation. Na JI, Choi SY, Yang SH, Choi HR, Kang HY, Park KC. J Eur Acad Dermatol Venereol. 2013 Aug;27(8):1035-9. doi: 10.1111/j.1468-3083.2012.04464.x. Epub 2012 Feb 13. Melasma is associated with an increased density of blood vessels Tranexamic Acid (TA) acts on inhibition of plasmin…
DetailsExtra-facial melasma: clinical, histopathological, and immunohistochemical case-control study. Ritter CG, Fiss DV, Borges da Costa JA, de Carvalho RR, Bauermann G, Cestari TF. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1088-94. doi: 10.1111/j.1468-3083.2012.04655.x. Epub 2012 Jul 24. Melasma is a common pigmentary disorder in women in their childbearing years taking the oral contraceptive pill. Its location…
DetailsVitiligo affects 2 to 3% of the population. Although useful treatments exist (topicals, phototherapy, grafting) it doesn’t always response and segmental vilitgo if particularyl challenging. In resistant cases it might be useful to fully integrate the importance of camuouflaging: it can be temporary (make up, self tanning creams…) or permannt (tattoos…) In a study…
DetailsThyroid dysfunction comprises hypothyroidism and hyperthryoidism. Autoantibodies against thyroglobulin and thyroperoxidase are found and the thyroid can still remian functional (normal levels of TSH + F4) 4-21% of patients have these autoantibodies The prospective study (626 patients) found that: 21% had thyroid stigma (n=131) subclinical hypothyroidsism was found in 51 patients Results suggest that…
DetailsDoes food have an impact on sebeaceous glands ? Sebacous glands appear to play another role: They concentrate and metabolize food stuffs More precisely, they concentrate exogeneous compounds (xenobiotics) from foods The liver appears not to play its role of the liver which would normally be expected to metabolize these foodstuffs. The sebocyte would therefore…
DetailsBleomycin is a chemotherapeutical cancer treatment generally for soft cell neoplasia Incidence of bleomycin-induced hyperpigmentation would reach 20% of all patients taking bleomycin The authors describe the case of a 23 year old woman who had ovarian dysgerminome. Treatment of bleomycin was given at a dosage of 30mg every week. 4 weeks after beginning the…
DetailsThe study compares trichloroacetic acid (TCA): treatment applied every 2 weeks up to 8sessions vs double frequency Q-switched Nd;YAG laser (1064nm and 532nm): treatment done once a month up to 6 sessions Methods (and comments) 65 adult female patients were included Wood’s light to determine depth (sometimes unreliable) Evaluation through MASI: not reliable (Link) Follow…
DetailsThe authors introduce the “DP-3 unifying concept”: acts on melanogenesis and melanosome transfer Study Formulation was applied twice daily in 33 women aged 31 to 68 Methods used and comments MASI: unreliable (Link) Physician global assessment (PGA) Photographic assessment: although it is claimed that a “significant depigmenting effect was demonstrated”, the pictures are not very…
DetailsAxillary hyperpigmentation is a common complaint among darker skin types. After having excluded postinflammatory hyperpigmentation (PIH), acanthosis nigricans (and pseudo-acanthosis nigricans), and done the necessary investigations there comes the time when a treatment option is asked by the patient. Study from India. Effect of topical 2% kojic acid + desonide 0.05%. Method: Double blind (triple…
DetailsIn the study use of either pimecrolimus 1% cream on one lesion twice a day or mometasone furoate 0,1% ointment on a second lesion in the evening or pimecrolimus 5 days a week and 2 days with mometasone furoate on a third lesion Randomized control study: included 50 children aged 2 to 18 treatment was…
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