PDT (Thérapie photodynamique) contre le carcinome basocellulaire (CBC) chez les asiatiques

Basal Cell Carcinoma (BCC) is less common in the Asian population Pigmented variants are more common which suggests that PDT (Photodynamic Therapy) is not the most recommendable treatment for this population group The study concerned 45 patients with 95 lesions and included only those with phototypes IV and V: clearance rate at 4 months was…

Résistance aux traitements contre la lèpre (maladie de Hansen)

Historical Events in the treatment of Hansen’s disease (Leprosy). 1943 – Paget reported promin treatment (sulphone) 1949 – dapsone introduced 1981 – MDT (Multi Drug Therapy) introduced 1964 – Dapsone resistance reported 1976 – Rifampicin resistance reported 2005 – Quinolone resistance reported 2007 – Cases of Resistance to MDT in 2007 reported 2009 – The…

Traitement des précanceroses par la PDT (phothérapie dynamique) chez les asiatiques

Indications for PDT (Photodynamic Therapy) generally speaking include: Actinic Keratosis (AK): in Asian patients few studies are available One study enrolled 43 patients with 58 AK (located on the face) 85% cleared after 1 treatment at 4 weeks follow-up. Bowen’s disease (Squamous-Cell Carcinoma in situ): in a Singaporean study 43 patients were recruited lesions were…

Déformation de le main provoquée par la maladie de Hansen: la main en griffe (Claw hand)

Claw hand is the most common deformity in leprosy: It is due to paralysis of the intrinsic muscles hand which is innervated by the median and/or ulnar nerves. Leads to hyperextension of MCP (metacarophalangeal) joints and flexion of the IP (interphalangeal) joints. Management consists of occupational therapy and/or reconstruction surgery. In this case report from…

Les kératoses actiniques au Japon

Actinic Keratosis (AK) in Japan: tend to be multiple 20% evolve into Squamous Cell Carcinoma (SCC) clinical types: macular, horn, papular, actinic cheilitis. All types can be pigmented: atypical keratinocytes containing melanin granules in the cytoplasm Aging of AK and histological caracteristics: early AKs: no parakeratosis atypical keratinocytes limited to the basal layer no budding…

La Qualité de vie chez les personnes atteintes d'handicaps induites par la lèpre

Leprosy is a debilitating infectious disease prevalent in Brazil, India and Vietnam. The Authors sought to assess disabilities and impairment of quality of life in Ho Chi Minh City, Southern Vietnam. Study: 160 patients with leprosy induced disabilites answered a questionnaire WHO quality of life-BREFassessment questionnaire Results from the BREF questionnaire; scores: physical subdomain score …

Pièges à éviter lors du traitement de lésions pigmentées et tatougages avec le laser

Beware of skin colored tattooos (e.g around the mouth): Why ? There is high risk of pigment darkening upon removal (eg Q switched laser): thie pigment turns black (oxydation reaction) Solution: use COs laser ablation: superficial   Beware of gold: Why ? if gold therapy was used for treatment of rhematoid arthririts, chrysiasis (deposit of…

Lèpre en Indonésie par rapport au reste du monde

Leprosy is not yet 100% eliminated but improving thanks to MDT (Multidrug Therapy)…but less and less aattention is devoted to it (only 25 attendees are present) Leprosy is part of the Neglected Tropical Diseases (NTD) according to the WTO http://www.who.int/neglected_diseases/diseases/en/) There are 3 in Indonesia when compared with Brazil The 3 NTD’s in Indonesia are…