Phototherapy: How does it work ?

Phototherapy is widely used in dermatology for the treatment of various skin conditions such as psoriasis, eczema, vitiligo, scleroderma and the list goes on and on. Different light spectrums, such as ultraviolet A (UVA), UVB, narrow band UVB…are used. Although poorly understood, suggested mechanisms are: Immune suppression (especially for UV): through immunoregulation by Langerhans cells,…

What's new in tattoo removal with lasers ?

Although tattoos are fairly easy to do they can be a challenge to remove. Why are lasers used for tattoo removal ? In the past tattoo removal involves tissue-destructive techniques including excision/grafting, dermabrasion, cryosurgery and electrosurgery. Although effective at removing the tissue pigments, these techniques often cause scaring, textural changes, keloids and permanent dyschromia. Lasers…

"Albinism": in fact a symptom part of Albinism and of a number of syndromes

Albinism is a rare genetic condition affecting around 1 out of 17000 individuals (can vary geographically). Albinism is characterized by severe and handicapping deficits in the visual system in association with a most variable hypopigmentation phenotype: visual defects include: foveal hypoplasia, reduced pigmentation of retinal pigment epithelium cells, misrouting of the optic nerves at the…

The role of blood vessels in melasma (chloasma, pregnancy mask): therapeutical implications

Melasma (Chloasma, Pregnancy Mask) is a common pigmentary condition and although it occurs more often in females and that hormonal factors may play a role, it is still incompletely understood. Clinically: In the lesions, telangiectasia (dilated broken blood vessels), tend to be present and melasma lesions have more vascularization when compared with the perilesional skin.…

Atteinte nerveuse dans la maladie Hansen (lepre): regardez les ongles !

Leprosy (Hansen’s disease) is an often ignored skin disease and this infectious disease can sometimes affect the nervous system. Non-specific nail changes can be found in Leprosy. The authors sought to study nail changes in leprosy: In this study cases of Hansen’s were collected from August 2011 to April 2012 (exclusion congenital nail deformities, fungal…

PDT (thérapie photodynamique) pour traiter l'acné dans la population asiatique

PDT (Photodynamic therapy) acts through the elimination of the bacteria Propinibacterium Acnes Short contact with the photosensitizing substance is enough (less than 90 minutes vs around 4 hours for conventionnal indications) More effective for papulopustular lesions (vs comedonal) phototypes II and III carry a lower risk of (postinflammatory hyperpigmentation) PIH following treatment.   The authors…