Protection against Ultraviolet Light (UVB) with Phloretin Sulfate

The phenolic compound phloretin: is a member of dihydrochalcones is found in apples and apple juice Phloretin 3,3 disulfonate (P33D) is obtained after its sulfonation with sulfuric acid Pure concentrated Phloretin sodium sulfonate was added to Human Cell cultures which were irradiated with UVB 20 mJ/cm2 Results show that reduced amounts of P33D were found…

Details

Molecules AGAINST Tanning in the cosmetic world

In early 20th century Europe, it was considered a mark of « low-class », as it was assimilated with outdoor professional activities. It is quite fashionable to tan in Western societies (Europe and North America), but is definitely not fashionable in Asia. Tanning is a process induced by ultraviolet light and is a protective mechanism to shield…

Details

Alopecia Areata: additional treatment options

Alopecia Areata (AA) is an inflammatory cause of non-scarring alopecia which carries a lifetime risk 1.7% Treatment options now available include, topical and intralesional steroids, Diphencyprone (DCP), oral steroids (in pulse dose) Genetics is poorly understood: innate and adaptive immunity The cause of the infiltrate of T cells at the base of hair follicles is…

Details

Young Skin or when the Cell Nucleus can communicate with the Cytoplasm (Cytosol)

The nuclear membrane separates the nucleus from the cytosol (cytoplasm) several proteins shape are part of its different layers. its role is to maintain mRNA and protein trafficking Lamin A and C are 2 of the main proteins. Its coding gene LMNA is mutated in the premature aging syndrome called the Hutchinson-Gilford progeria syndrome Progerin…

Details

The Potential Role of Non-Collagen Proteins in Skin Aging

Cartilage oligomeric metric protein is part of the « non-collagen » proteins of the extracellular matrix and interacts with collagen I via fibril associated fibrils XII and XIV was previously only found in cartilage In fibrotic skin such as in localized scleroderma (morphea) wound tissue and exudates of patients with venous ulcers and in the stroma of…

Details

How the action of Cyclosporine helps in understanding anti-Il17 and anti-Il23 biologics

When looking at psoriasis lesions, numerous T cells are present. In 1979, cyclosporine was shown to act on psoriasis as a T cell suppressor. Nevertheless, at that time but it was also shown to have an antiproliferative action on keratinocytes. Result: the biological action (cytokine inhibition) was overlooked. T cells are stimulated by antigen presenting…

Details