Psoriasis-induced by Injected anti-TNF drugs (Paradoxical adverse, reactions): Oral non-TNF targeted therapies ?

The development of psoriasis has been observed in anti-TNF therapies for the treatment of Rheumatoid Arthritis, Ankylosing Spondylitis and Behcet’s disease. Its incidence is estimated to occur in around  5% of cases and is more frequent in females than males. It occurs 5 days to several months after the initiation of treatment in patients in…

Details

Ultraviolet Damage: which layer do the Cytotoxic molecules come from ?

Ultraviolet damage mostly comes from the generation of Reactive Oxygen Species (ROS) The enzymes responsible for the synthesis of ROS (oxygen singulets, O2. and 1O2) are Superoxide Dismutase (SOD) and Catalase. They are present in higher quantities in in the Stratum Corneum (SC) than in the lower epidermis and dermis Carbonylated Proteins (CP) are the…

Details

Rhododenol (Rhododendrol) – induced toxicity appears to happen at higher concentrations and the protective mechanism it triggers

Not all consumers developed white blotching after applying rhododendrol (rhododenol)-containing products All treatment areas didn’t necessarily develop white blotchingThe authors performed cell cultures on normal human melanocytes Results high doses (1500micromol and 3000micromol) had a cytotoxic effect apoptosis was observed at 3000micromol (through activation of caspase 3) low doses of 300-900micromol inhibited melanogenesis (downregulation of…

Details

Rhododenol-induced cyotoxicity: proposed mechanism of action

Rhododenol (Rhododendrol) is phenolic compound known to induce leucoderma. Another similar compound causing this is hydroquinone monomethyl ether The authors did a study in human melanoma B16f10 cells: Rhododenol 4, 4-hydroxyphenyl (R44HPB) 2-butanol increased The ROS (Radical Oxygen Species) H2O2 in B16f10cells The increase in the ROS H2O2 occurs when R44HPB is oxydized into quinone-tyrosinase.…

Details

Rhododenol (Rhododendrol)-induced leukoderma: an objective way to ascertain normalization of the skin

This study suggests an objective way to follow-up of rhododenol-induced vitiligo by skin absorption spectrum analysis A word on Rhododenol (Rhododendrol): Rhododendrol (Rhododenol) is is derived from the white birch tree it inhibits tyrosinase activity and melanin synthesis Vitiligo-like lesions were observed and in march 2014, 14000 cases were reported in Japan alone In this…

Details

A tool to study Rhodenol (Rhododendrol) induced leucoderma (Vitiligo-like lesions)

Rhododendrol (Rhododenol, RD) created a big problem in Japan, when 14000 induced cases of vitiligo-like lesions were reported. It is known that Rhodoendol is cytoxic against melanocytes in a Tyrosinase dependent way cytotoxicity The authors suggest a new mouse model for the study of this effect: hk14-scf/HRM Tg Mice become albino (fully depigmented) through suppression…

Details