Acitretin: is a metabolite of etretinate is FDA-approved for use in psoriasis is less lipophilic than the former and fat storage (half life 120 days): It is highly highly toxic to embryos during pregnancies (teratogenic) and contraception in women must be used for at least 2 years (come say 3 three years) no safe dosage:…
DetailsDemographics and Economics India is a populous country with close to 1.3 billion individuals. But contrarily to China it is still growing. Nevertheless, the Gross Domestic Product (GDP) is only US5 trillion (United States US16 trillion) and only 3.9% of GDP expenditure is for healthcare (United States: 17.9%) Enough dermatologists ? In absolute terms there…
DetailsDermal needle treatment in acne scars (poster) Ertam I et al. AAD 2015 Annual Meeting, San Francisco CA – United States Acne scars are the long-term visible sequelae of more or less severe active acne. The demand for its treatment is in our experience is quite high and reaches 20% of those who had treatment…
DetailsApremilast for atopic dermatitis: reversing interleukin-4 dysregulation on primary human keratinocytes (Poster) Mohan GC et al. AAD 2015 Annual Meeting, San Francisco CA – United States INTRODUCTION Apremilast (Otezla) is an oral treatment for plaque psoriasis. It is a small molecule which acts through inhibition of phosphodiesterase 4 (PDE4) (In atopic dermatitis (AD), there is…
DetailsCost per responder of apremilast versus etanercept, adalimumab, and ustekinumab in Patients with moderate to severe psoriasis (Poster) Feldman SR et al AAD 2015 Annual Meeting, San Francisco CA – United States With the injected biologics treatment for psoriasis and the newer oral « small molecules » for the treatment of psoriasis the authors found it useful…
DetailsIntroduction The drug is called apremilast under the brand name Otezla It is indicated in patients with moderate-to-severe plaque psoriasis Studied since 2004 in clinical trials in over 3500 patients Is it effective ? In a randomized-control trial 1257 with moderate-to-severe psoriasis and evaluated after 16 weeks (after a week of progressively increasing dosage) The…
DetailsKarl Marx (1818-1883) is a socialist philosopher of the 19th century who is the father of modern communism (Marxism-Leninism)…and authored the Communist Manifesto (with F.Engels), one of the most important documents of the 19th century. Many countries had adopted this state mode of functioning and it counter-balanced capitalism. Marx had Hidradenitis Suppurativa (Verneuil’s disease) and…
DetailsMorgan Freeman (b. 1937) is an African-American actor who displays brownish « stuck-on » papules around the eyes. These lesions are compatible with a type of seborrheic (seborrheic) keratosis called Dermatosis Papulosa Nigra (DPN) Even though the lesions are benign many choose to have them removed for cosmetic reasons. Treatment carries a risk of post-inflammatory hyper pigmentation…
DetailsJoseph Stalin (1878-1953; Ioseb Besarionis Dze Jugashvili; Ио́сиф Виссарио́нович Ста́лин) was the leader of the Soviet Union from the mid 1920s to his death in 1953. He had smallpox in childhood and at the age of 7 which left him badly scarred. The marks are meticulously hidden by the censorship. However they are visible in…
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