Rosacea is a common dermatological condition affecting 0,5 – 1 % of the population which represents over 15 million individuals in the United States It is sometimes classified in stages 1 (erythema and telangiectasia), 2 and 3 (rhinophyma). It is an important cause of distress and social withdrawal. Around 60% of individuals with stage 1…
Rosacea is still a mystery with regards to etiology but it has been suggested that the Demodex mite might be associated with its presence and/or severity. Canthelicidines are antimicrobial peptides that protect the skin through: direct antimicrobial activity by initiating a hosp response resulting in cytokine release, inflammation, angiogenesis and reepitheliazation. In rosacea the…
Systematic review of oral treatments for seborrheic dermatitis. Gupta AK, Richardson M, Paquet M. J Eur Acad Dermatol Venereol. 2014 Jan;28(1):16-26. doi: 10.1111/jdv.12197. Epub 2013 Jun 26. Seborrheic dermatitis (SD) is a common inflammatory disorder which affects: the scalp where it creates flaking of the skin or what is known as common dandruff (Pityriasis capitis).…
Serum granulysin as a possible key marker of the activity of alopecia areata. Ono S, Otsuka A, Yamamoto Y, Kataoka TR, Koyanagi I, Miyachi Y, Kabashima K. J Dermatol Sci. 2014 Jan;73(1):74-9. doi: 10.1016/j.jdermsci.2013.08.009. Epub 2013 Sep 2. Alopecia areata (AA) is an auto-immune inflammatory dermatosis of the scalp resulting in non-scarring rounded patches of…
The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. Egbert M1, Ruetze M2, Sattler M1, Wenck H1, Gallinat S1, Lucius R3, Weise JM4. J Dermatol Sci. 2014 Jan;73(1):40-8. doi: 10.1016/j.jdermsci.2013.08.010. Epub 2013 Sep 3. Skin aging can be seen: on the epidermis by changes in texture and color. in…
Subtypes 1, 2 and 3 have different upregulated genes. However there is a 20-30% overlap in the similarity of the genes being upregulated. Rosacea can be divided into two distinct forms; In the typical form, rosacea can progress from subtypes 1, 2 and 3. But not necessarily as we know that there are genetic similarities,…
Melanoma often goes undetected, especially in children. Indeed, because of its lower incidence there is often a low index of suspicion. Melanoma detection is a well-established science and the ABCDE criteria is a well established technique (combining wth dermoscopy if possible). Here is what the criteria stand for: A for Asymmetry B for Border irregularity…
Adult female acne: a new paradigm. Dréno B, Layton A, Zouboulis CC, López-Estebaranz JL, Zalewska-Janowska A, Bagatin E, Zampeli VA, Yutskovskaya Y, Harper JC. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1063-1070. doi: 10.1111/jdv.12061. Epub 2013 Jan 10. Adult female acne is a problem. Indeed 12% of females at age 40 still have acne. Most have…
Effect of tranexamic acid on melasma: a clinical trial with histological evaluation. Na JI, Choi SY, Yang SH, Choi HR, Kang HY, Park KC. J Eur Acad Dermatol Venereol. 2013 Aug;27(8):1035-9. doi: 10.1111/j.1468-3083.2012.04464.x. Epub 2012 Feb 13. Melasma is associated with an increased density of blood vessels Tranexamic Acid (TA) acts on inhibition of plasmin…
Extra-facial melasma: clinical, histopathological, and immunohistochemical case-control study. Ritter CG, Fiss DV, Borges da Costa JA, de Carvalho RR, Bauermann G, Cestari TF. J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1088-94. doi: 10.1111/j.1468-3083.2012.04655.x. Epub 2012 Jul 24. Melasma is a common pigmentary disorder in women in their childbearing years taking the oral contraceptive pill. Its location…
