About lentigo solaris (solar lentigo, lentigines): Occurs in sun exposed areas typically in individuals aged 50 and over Histologically, pigmentation is located in the epidermis, in the basal layer. (Stratum basale) It is caused by an increased number of melanocytes who have a normal amount of melanin Treatment options include: cryotherapy chemical peels Solar lentigines…
DetailsPost-inflammatory hyperpigmentation is located in the dermis. Wood’s lamp is useful to diffrentiate with other pigmentary disorders such as melasma (chloasma, pregnancy mask) Causes include: infections allergies mechanical factors or trauma phototoxic and photoallergic (cosmetics) reactions inflammatory skin conditions (lichen planus, Systemic Lupus Eythematosus (SLE)) Treatment: the condition is spontaneously resolutive over a few months…
DetailsEpidemiology Melasma (chloasma, pregnancy mask) is more frequent in Caucasian individuals with the following genetic factors: In Germans, Poles and Russians In individuals of Jewish descent (location is typically on the the face) If we take into account skin phototypes (Fitzpatrick): types I and II phototypes tend to have melasma before pregnancy and in young…
DetailsThe authors seek to measure the effet of 4-n-butylresorcinol to treat pigmented spots by comparing it with hydroquinone, arbutin and kojic acid. Hypothesis: Tyrosinase is the enzyme enabling the production of melanin. Many studies only investiage tyrosinase in mushrooms and mice melanoma cells These substances are not necessarily inhibitors of human tyrosinase Study Comparison of…
DetailsThe following conditions can be found in the Caucasian population (non-exhaustive list): Freckles (Ephelides): increased amount of melanin with normal number of melanocytes lentigenes (solar lentigo): appear after 50 years old. Histologically: epidermal pigmentation located mainly in the basal layer Caused by an increase number of melanocytes (containing a normal amount of melanin) Solar hyperpigmentation:…
DetailsSystemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine. Walling HW. J Am Acad Dermatol. 2012 Mar;66(3):387-92. Epub 2011 Aug 4. Hyperhidrosis is a socially bothersome and psychologically devastating condition which occurs spontaneously, but can reach extreme proportions in hot and humid wethaer conditions. Treatment options appear to…
DetailsPresented at the Scientific Meeting: European Academy of Dermatology (EADV), Annual Meeting. Prague (Praha), Czech Republic (Česká republika, Česko), 27 – 30 September 2012 Hsu.C. 1, Pourahmadi M.2, Ahmadi S. 2, Ali Mahdi H. 3 1:Centre Medical du Lignon, Geneva, Switzerland. 2: Jahrom University Medical school, Jahrom, Iran. 3: Global Dermatology Information Portal. Royal Bahrain…
DetailsThis is particularly useful when the diagnosis is not obvious from clinical examination* (nails, extensor surfaces (elbows), folds on the face): Psoriasis lesions appear reddish Seborrheic Dermatitis (Seborrhoeic Dermatitis) lesions appear yellowish *It is typical to have this problem when the lesions are located on the scalp only Use a dermatoscope and look at the…
DetailsThe new generation (that is non-hydroquinone based) depigmentation creams also work… They are not as a group more effective than hydroquinone-based topicals(HQ)… …However they do have a much lower frequency and severity of side-effects Contributors: Dr Christophe HSU – dermatologist. Geneva, Switzerland Source of Information: 2012 (09) – Sachdev M. 21st Annual Congress of the…
DetailsHormones only provide a partial explanation to the pathogenesis of melasma (chloasma, mask of pregnancy) In a study involving 400 pregnant women: 16% of them had melasma even though it was not related to the stage of pregnancy Also the pigmentation was located more often on the arms which is an atypical distribution for melasma.…
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