Atopic Dermatitis: a Short Summary
This study suggests an objective way to follow-up of rhododenol-induced vitiligo by skin absorption spectrum analysis
- A word on Rhododenol (Rhododendrol):
- Rhododendrol (Rhododenol) is is derived from the white birch tree
- it inhibits tyrosinase activity and melanin synthesis
- Vitiligo-like lesions were observed and in march 2014, 14000 cases were reported in Japan alone
In this study the photo-spectrometric character of vitligo-like lesions was done using multi band filtered digital camera:
-skin color absorbance was done between 370nm and 780nm
- in 19 subjects with rhodenol-induced vitligo
- in 9 subjects with vitiligo vulgaris (normal vitiligo)
- in 4 controls
Results:
-the absorbance window was relevant between 420 and 460nm
-maximum absorbance was lower for vitiligo and rhododenol-induced vitiligo when compared with controls
-maximum absorbance was higher for rhododenol-induced vitiligo than vitligo vulgaris
-6 months after stopping rhododenol, absorbance is close to that of healthy skin (and significantly different from baseline) (this is correlated with a clinically visible repigmentation)
(Absorbance for vitiligo vulgaris also increased with steroids, tacrloimus, and when both were combined. This was NOT observed with vitamin D application)
Comment: despite having generated a big health issue because of leucoderma, it seems that the lesions induced are slowly reversible and that the absorbance is comparable to normal skin 6 months after rhododenol is stopped.
Contributors
Dr Christophe Hsu – dermatologist. Geneva, Switzerland
Source of information: p13-24 Inoue M. et al. Comparison of vitiligo vulgarism and rhododenol-induced vitiligo by multi band camera imaging with multiple linear regression analysis. JSID Annual Meeting (Japanese Society of Investigative Dermatology, 日本研究皮膚科学会) 2014 – Osaka, Japan
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