Atopic Dermatitis: a Short Summary
- Bleomycin is a chemotherapeutical cancer treatment generally for soft cell neoplasia
- Incidence of bleomycin-induced hyperpigmentation would reach 20% of all patients taking bleomycin
- The authors describe the case of a 23 year old woman who had ovarian dysgerminome. Treatment of bleomycin was given at a dosage of 30mg every week. 4 weeks after beginning the treatment, she developed flagellate hyperpigmentation (itchy, located on trunks and extremities )
About flagellate hyperpigmentation
- It occurs anywhere from 24 hours to 9 weeks after first administration
- The cumulative dose of bleomycin reaches 100 to 300mg
- Etiological hypotheses:
- scratching the skin and irritation from clothing (due to drug toxicity)
- intracellular accumulation of melanin
- It usually fades in 4 months after the drug is stopped
Source of information. Cayirli M. et al. Bleomycin induced flagellate hyperpigmentation – a case report. p1411. European Academy of Dermatology and Venereology (EADV) Annual Meeting – Istanbul, Turkey, 2-6 October 2013
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