Atopic Dermatitis: a Short Summary
- The authors constructed the molecular regulatory network of melanogenesis by focusing on 2 pathways:
- paracrine factor-mediated signaling pathway
- Microphthalmia-associated transcription factor-related pathway
- By reviewing the literature, the authors established a “Boolean network model” that describes the dynamical characteristics of the network:
- Molecules which would decrease pigmentation: CREB, MITF protein, MITF active, GSK3B, CAMP, AC, PKA, Gprotein.
- Molécules which would increase pigmentation: DSH, FZ.
- They experimentally validated the skin lightening effect of these targets through chemical inhibition such as with beta-catenin inhibitors.
- Comment: This very interesting poster cenceptualizes (mathematically calculated) targets of skin lightening treatments which would have no regulatory effect on the viability of the keratinocytes or melanocytes.
Contributors:
Dr Christophe HSU – dermatologist. Geneva, Switzerland
Source de l’Information: H Lee,1,2 M Goh,3 J Kim,1 T Choi,1 H Lee,3 Y Na3 and K Cho1,2 1Lab. for Systems Biology and Bio-Inspired Engineering, KAIST, Daejeon, Republic of Korea, 2Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea and 3Skin Research Institute, Amorepacific R&D Center, Yongin, Republic of Korea. Systems biological identification of effective and safe molecular targets for skin lightening. International Investigative Dermatology (IID) 2013 – Edinburgh, United Kingdom
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