4-Hydroxyanisole (4-OHA)

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4-OHA is a skin depigmenting agent with moderate efficacy and may be used for the treatment of hyperpigmentary disorders such as melasma and freckles.
This agent decreases the number of melanin producing cells in the skin and can whiten the skin to a considerable degree.
However, one should be aware of possible side effects such as skin irritation.
Non-uniform depigmentation does not usually occur using 4-OHA. 4-OHA products are applied once to twice daily and the skin whitening effect usually becomes evident after 3-4 weeks of application. The maximum whitening effect is reached within 6-8 weeks. Thereafter, the product may be applied once to twice weekly to maintain the whitening effect. The combination of 4-OHA with tretinoin greatly enhances the whitening activity of 4-OHA.

Rhododénol
30 July 2013