L’acide Kojique
- Rhododenol is also called 4-(4-hydroxyphenyl)-2-butanol.
- It is manufactured by Kanebo cosmetics and has been on the market since 2008.
- It is naturally produced and has been approved for the management of pigmentary problems (Melasma, Sun spots, Lentigo…)
- It is a phenolic compound therefore it is potentially melanocytoxic. It acts by reducing the activity of tyrosinase through and therefore inhibits the production of melanin (skin pigment).
- Hydroquinone is another phenolic compound which is also toxic to pigment cells.
- Earlier in July 2013, it was removed from the market because of a massive incidence of white vitiligo-like patches on areas where the cream was applied (white blotches): Phenols and catechols with an alkyl group attached to the para position of the ring (such as para-isobutyl catechol) have caused occupational vitiligo in humans. The longer the alkyl chain the higher the risk of depigmentation.
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