Demographics and Economics India is a populous country with close to 1.3 billion individuals. But contrarily to China it is still growing. Nevertheless, the Gross Domestic Product (GDP) is only US5 trillion (United States US16 trillion) and only 3.9% of GDP expenditure is for healthcare (United States: 17.9%) Enough dermatologists ? In absolute terms there…
DetailsGlobal photographic assessment of men aged 18 to 60 years with male pattern hair loss receiving finasteride 1 mg or placebo. Olsen EA, Whiting DA, Savin R, Rodgers A, Johnson-Levonas AO, Round E, Rotonda J, Kaufman KD; Male Pattern Hair Loss Study Group. J Am Acad Dermatol. 2012 Sep;67(3):379-86. doi: 10.1016/j.jaad.2011.10.027. Epub 2012 Feb 9.…
DetailsAge-related changes are due to many factors influencing the structure of the epidermis (texture changes) as well as changes in the dermis (loss of volume). The following study shows the role of hyaluronic acid (HA), BOTH large and small fragments in Epidermal age related skin changes. This study shows that topical application of small HA…
DetailsCentral to that is calcium regulation which allows changes in cellular differentiation. The N-methyl-D-aspartate receptor (NMDAR) is important for this and is abnormally expressed in psoriasis lesions. In this study, the speed of wound healing is suggested to be faster in psoriasis wounds as compared with wounds of unaffected individuals. Psoriasis shares many things in…
DetailsAndrogenetic alopecia is an often hereditary condition with thinning of the hair into vellus hairs which occurs in males and females according to a male pattern (Hamilton classification) or a female pattern (ludwig classification) It is psychologically devastating and treatments include topical (minoxidil), oral (finasteride) treatments sometimes so ineffective that the only solution is wearing…
DetailsSkin aging (ageing) concerns the skin, in the epidermis where it is responsible for texture changes. However the most visible effect of aging is loss of volume in the dermis. In the dermis intact collagen fibers (as well as hyaluronic acid) play an important structural role in its volume. The visible changes in aging are…
DetailsFumaric acid esters (FAE) (oral intake) are used in come countries (Germany…) in the treatment of psoriasis. It is an effective drug however its limitations lie in the fact that it can cause gastrointestinal symptoms as well as flushing In this retrospective study from Ireland done in 249 patients, demographic data, length of treatment, reasons…
DetailsExtracorporeal photophoresis (ECP) has been used for the treatment of cutaneous T cell lymphoma, including graft versus host disease (GVHD), solid organ transplant rejection, scleroderma, atopic dermatitis, epidermolysis bullosa acquisita, lichen planus, lupus erythematosus, pemphigus vulgaris, Crohn disease, and type 1 diabetes. This article is a casease report of a rare autoimmune hemolytic anemia called…
DetailsPemphigus vulgaris is an autoimmune bullous skin disease which is divided into pemphigus vulgaris (disorder of desmoglein 3) and Pemphigus foliaceus (desmoglein 1, endemic form=fogo selvagem). This consensus has all its sense especially for pemphigus vulgaris as it is a non curable disease. Therefore it is very important to be able to classify disease states,…
DetailsIt is not exactly a secret that when things go wrong in lymphocytes, which are so important in immunosurveillance, there are consequences on the organism’s defense against external agents. Conversely, as this review shows, infectious agents might be able to regulate T lymphocytes. Soft cell tumors affect lymphonodes, but they can initially affect the skin…
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