Adalimumab showed a slightly higher reduction in PASI after 1 year, however it proved an equivalent efficacy to Etanercept after an extensive follow-up (up to 5 years) Contrarily to etanercept, adalimumab patients showed a progressive improvement with DLQI (84 to 77) For both groups, sustained response (PASI75 maintenance of results 60 months after initiation of…
Infliximab is an anti-TNF biologic It is used in the treatment of rheumatoid arthritis, psoriasis and inflammatory bowel disease A case report from Spain: 32 year old female known for Crohn’s disease no response to mesalazine and systemic corticosteroids was subsequently put on infliximab at a dosage 5mg/kg for a duration of 10 years she…
In this Indian study, protein samples of Mycobacterium Tuberculosis (similar to the one used in the Mantoux screening test) were used: PPD – purified derivative of M.Tuberculosis 10IU PPD 0,1ml indication: facial and palmoplantar warts or more than 15 (no mention of genital warts) 2.5 IU (or TU: Tuberculin Units) on left forearm 2.5 IU…
Facts about facebook Most visited website in the world with 1.3 billion users 72 % visit the website at least once a month 829million daily users Duration of each visit lasts on average 21 minutes Facts about Twitter 1 billion users 550 million accounts BUT 44% never tweeted 271million monthly users average time per month…
What “apps” are available and do they work ? At the time of this presentation about 1 million apps are available app store 50 billion downloads 17000 apps are health-related – evidence about their reliability is mostly lacking. They are projected to generate $26 billion revenue in 2017 In 33% physicians are NOT involved in…
Incidence of Acne in the first 20 years of life: -3% of affected individuals are neonates -6% in childhood (pre-adolescents) -91% in teenagers (adolescents…predictably) Thorough examination must be done in children to rule out differential diagnosis: -keratosis pilaris -miliara -perorificial dermatatis -pomade acne (cosmetic use) -flat warts -molluscum contagiosum Scarring is a complication…
Age-related changes are due to many factors influencing the structure of the epidermis (texture changes) as well as changes in the dermis (loss of volume). The following study shows the role of hyaluronic acid (HA), BOTH large and small fragments in Epidermal age related skin changes. This study shows that topical application of small HA…
Central to that is calcium regulation which allows changes in cellular differentiation. The N-methyl-D-aspartate receptor (NMDAR) is important for this and is abnormally expressed in psoriasis lesions. In this study, the speed of wound healing is suggested to be faster in psoriasis wounds as compared with wounds of unaffected individuals. Psoriasis shares many things in…
Androgenetic alopecia is an often hereditary condition with thinning of the hair into vellus hairs which occurs in males and females according to a male pattern (Hamilton classification) or a female pattern (ludwig classification) It is psychologically devastating and treatments include topical (minoxidil), oral (finasteride) treatments sometimes so ineffective that the only solution is wearing…
One of the autoimmune systemic diseases which have extensive skin manifestations is mixed connective tissue disease or MCTD. This disorder is a combination of other autoimmune diseases such as lupus erythematosus, systemic sclerosis and polymyositis. The cause of this disorder is not completely known but is stipulated to be an effect of one’s immune system…
