L’alcool et la peau (éthylisme) – Table des matières
Pancreatitis
- Due to alcohol abuse in 65% of cases
- Clinically: Panniculitis
- also called nodular cystosteatonecrosis or cutaneous nodular adiponecrosis: mechanism thought to be due to the liberation of enzymes in the circulation directly or through lymphatic channels
- found in the male between 40 and 70 years old
- clinically: dermohypodermic inflammatory plaques predominantly located in the fingers and lower limbs with pain. Can lead to fistulisation and leakage of molten fat. Evolves in to cup-like depressions. Accompanied with fever, arthralgia, distal bone pain ( due to cystosteatonecrosis of the bone medulla).
- lab findings: elevation of serum amylase and lipase levels.
- histology: foci of adipocyte necrosis, beginning in the centrolobular area. The content of the adipocytes disappears and only the cypoplasmic membranes of these “ghost cells”. Finally formation of a lipophagic granuloma.
Bibliography: Dermatologie et Infections Sexuellement Transmissibles, 4th Edition
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