Daily Archives: Tuesday March 24th, 2015

Omalizumab (Xolair) for Urticaria Treatment

Omalizumab (Xolair): recombinant humanized monoclonal antibody that binds to the free Immunoglobin IgE (produced byB lymphocytes), more specifically on the C3 domain of the IgE heavy chain complete, it block free IgE. Unlike ordinary anti-IgE antibodies, it does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the…

Psoriasis Treatment with Biologics

Existing TNF-inhbitors: Adalimumab (Abbott) Infliximab (Janssen Bitotech and other biosimilars (generics) Etanercept (Amgen) Certolizumab (UCB) Il-17 antibodies Secukinumab (Cosentyx, Novartis): dosage: injected 300mg at weeks 0, 1, 2, 3, and 4 then 300mg or 150mg every 4 weeks, the doctor decides ! The price is the same for both doses ! Works in 3 weeks…

Psoriasis treatment with "small molecules"

Available “small molecules”: Apremilast (Otezla) inhibits phosphodiesterase 4 (PDE4) exhibits anti-inflammatory properties apart from PDE4 action, its complete effects are not fully known but it is known (at the time of writing) that it modulates inflammation by reducing TNF-alpha, Il-2, IFN-gamma, leukotrienes and NO synthases. The effect appears to act through increased intracellular cAMP accumulation…