The greek word from which this term comes from is : λειχην = leichen = lichen (dartrous) This denomination was given following botanics, to describe dermatoses defined by a gathering of papules or elevated lesions (plaques) which resemble lichen (or dartrous-like) On the famous tree of dermatoses by Alibert in 1828, dartrous (lichen-like) dermatosis figure…
Blaschko lines are a distribution of skin lines which can be found in certain dermatosis, often genetic. Examples include incontinentia pigmenti, epidermal nevus, lichen striatus… These lines carry the name of Dr Alfred Blaschko (1858-1922), a German dermatologist who described the lines on a statue and published the pictoral diagram in 1901. The cause of…
What is it ? It is the presence of pinpoint bleeding when the scales are removed from the surface of psoriasis lesions. In French, it is called “signe de la rosée sanglante” which translates to: dew which looks like blood There are full of histopathological details, but this is nothing surprizing from a master in…
Moriz Kaposi (1837-1902) was a Hungarian dermatologist practicing in Vienna, at the time the capital of the Austro-Hungarian Empire. He described Idiopathic Multiple Pigment Sarcoma of the skin in 1878 – now widely called Kaposi’s sarcoma. Since then it is not fully idiopathic anymore and is due to reactivation of the Human Herpesvirus type 8:…
Also known as Pityriasis Rosea of Gibert, it was named by a French dermatologist in 1860. Dr Camille Gibert (1797-1866) was a student of Laurent Biett, a Swiss dermatologist (who described the collarette of Biett, a sign of secondary syphilis). Gibert also made many inoculation experiments being able to demonstrate the contagiosity of secondary syphilis.…
In 1905 , the cause of syphilis was found by two German dermatologists: a spirochaete bacteria called Treponema Pallidum When presented at a meeting of the Berlin medical society, the president, Prof Ernst Von Bergmann, cut him short with words he no doubt later regretted. “This terminates the discussion – until the next cause of…
Epidemiology of Hidradenitis suppurativa (HS) also called Acne Inversa (Jemec) -Prevalence is anywhere between 0.0033% (genetic hypothesis) to 4% (self reporting in nurses) -In a big study in immigrants comparing with Spanish citizens, prevalence of HS was found to reach 0.2% up to 0.9% in Spanish citizens. prevalence is anywhere between 0.0033% (genetic hypothesis) to…
Erythrodermic psoriasis (EP) is a generalized, inflammatory erythematous dermatosis, with or without exfoliation lasting for at least 3 months involving 75% or more of the body surface Methods: In this retrospective study PASI evaluation was done at 4, 16 and 28 weeks of treatment 22 patients dosage of 45mg in 16 patients dosage of 90mg…
Brodalumab (KHK4827, also known as AMG827) is a monoclonal antibody that binds to human IL-17RA and blocks the biological activities of IL-17A, 17F, 17A/F and IL-17E It has been shown to improve plaque psoriasis and psoriatic arthritis in 12 weeks. Goal: efficacy of KHK4827 for nail nail and scalp psoriasis in Japanese patients with moderate…
Lipofucsin is the intracellular aggregate of oxidized proteins and lipids. It is a marker of autophagy and is stainable on immunochemistry with Sudan Black B (SBB) Ultraviolet A (UVA) damage induces DNA damage, oxidation of proteins and lipids, autophagy and subsequently apoptosis (provided exposure is long enough) In this study human cultures of fibroblasts were…
