The nuclear membrane separates the nucleus from the cytosol (cytoplasm) several proteins shape are part of its different layers. its role is to maintain mRNA and protein trafficking Lamin A and C are 2 of the main proteins. Its coding gene LMNA is mutated in the premature aging syndrome called the Hutchinson-Gilford progeria syndrome Progerin…
Royal-jelly is a yellowish material secreted from the hypopharyngeal and mandibular glands of worker honeybees. It has been shown to have a protective effect on dry skin (epidermal hydration) In this study, dietary (oral) supplementation was given: Total of 47 subjects (mean age: 41.3 years old +/- 6.2) capsules of 520mg taken once a day…
Cartilage oligomeric metric protein is part of the “non-collagen” proteins of the extracellular matrix and interacts with collagen I via fibril associated fibrils XII and XIV was previously only found in cartilage In fibrotic skin such as in localized scleroderma (morphea) wound tissue and exudates of patients with venous ulcers and in the stroma of…
When looking at psoriasis lesions, numerous T cells are present. In 1979, cyclosporine was shown to act on psoriasis as a T cell suppressor. Nevertheless, at that time but it was also shown to have an antiproliferative action on keratinocytes. Result: the biological action (cytokine inhibition) was overlooked. T cells are stimulated by antigen presenting…
Obesity is a public health problem It is also associated with psoriasis and the Th17 cell plays a role There is a link between Body Mass Index (BMI) and the prevalence of psoriasis: however the pathophysiological reason to this link is unknown…however this study tries to give an explanation The authors used a mouse obese…
The skin is routinely exposed to mechanical stimuli such as: stretching, contraction, compression, torsion Cyclical stretching : increases secretion of humoral factors and proteolytic enzymes by activating inflammatory signaling pathways in keratinocytes and fibroblasts induces degradation of the extracellular matrix …the response to it depends on the nature of the stimulus and its duration Methods…
Semi permanent tattoos are often used to alleviate tedious daily make-up but they also, like other tattoos can become cosmetically unacceptable. Treatment: Available classical treatments include, surgery, dermabrasion but both induce scarring which is not acceptable for patients who are looking for a cosmetic procedure to correct another one. Q-Switched lasers have been tried and…
Tuberous Sclerosis (TSC) is a multisytemic condition characterized by numerous skin signs (shagreen patch, ash leaf macules…). Of these, hypomelanotic macules are the most frequent sign and are present in 90% of patients with TSC. (Macules have to be 3 or more in number to fit in the diagnosis of TSC). The cause of TSC…
The Greek word of origin is: πομφολυξ = pompholyx = vesicle This term was given to what is now pemphigus by Robert Willan (a British physician, 1757-1817, the real founder of dermatology). Alibert (a French physician, 1766-1837) decided then to use this term for all bullous skin conditions originating from pemphix. This term will persist…
The cause of scabies was unknown and in the early decades of the 19th century, the mite being the cause of scabies were controversial. Simon François Renucci a Corsican medical student had seen native women remove mites from people with “the itch”; it amused him to see the professors of Paris in the dark. In…
