The role of melanocytes in skin pigmentation and how they are regulated

In mammals, the melanocyte and melanin are responsible hair color and protection of the skin from ultraviolet light (UV). In their development, melanocytes initally derived from neural crest cells, migrate to the basal layer of the epidermis and hair follicles. The migration and proliferation of these cells and the synthesis of melanin is a regulated…

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Phototherapy: How does it work ?

Phototherapy is widely used in dermatology for the treatment of various skin conditions such as psoriasis, eczema, vitiligo, scleroderma and the list goes on and on. Different light spectrums, such as ultraviolet A (UVA), UVB, narrow band UVB…are used. Although poorly understood, suggested mechanisms are: Immune suppression (especially for UV): through immunoregulation by Langerhans cells,…

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