Treatments in use and their evidence in the treatment of Melasma (Chloasma) (Pregnancy Mask) Evidence is classified from A (the best with the most evidence) to E A 4% hydroquinone + 0.05% retinoic acid (RA) + 0.01% fluocinolone acetonide B 4% hydroquinone (HQ) 0.1% tretinoin (RA) 2% HQ + 0.05% RA + 0.1% dexamethasone (Modified…
New Depigmenting substances: N-acetyl glucosamine Artocarpanone 4-n-butylresorcinol (rucinol) Ursolic Acid Anthraquinones Cinnamic Acid Macelignan Gallic Acid Glycine Isopanduratin A and 4-Hydroxypanduratin A Kurarinol, Kurarinidol and Trifolirhizin Pycnogenol 8% topical indomethacin cream Selina dien-8-one Taxifolin DeoxyArbutin and its second generation derivatives Hydroperoxy Traxastane t; type Triterpene Piceatannol Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th…
New Depigmenting substances: N-acetyl glucosamine Artocarpanone 4-n-butylresorcinol (rucinol) Ursolic Acid Anthraquinones Cinnamic Acid Macelignan Gallic Acid Glycine Isopanduratin A and 4-Hydroxypanduratin A Kurarinol, Kurarinidol and Trifolirhizin Pycnogenol 8% topical indomethacin cream Selina dien-8-one Taxifolin DeoxyArbutin and its second generation derivatives Hydroperoxy Traxastane t; type Triterpene Piceatannol Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th…
Prevention: primary: no vaccine available Vaccination against tuberculosis (TBC) also called BCG (Bacille Calmette Guerin against tuberculosis) has some effect secondary=early diagnosis and treatment: chemoprophylaxis (treatment of subclinical leprosy) (destined to those in potential contact) and immunoprophylaxis: single dose of rifampicine 300mg-600mg according to weight tertiary: prevention of disability leprosy (Hansen’s Disease) and TBC BCG…
Epidemiology: cause: mycobacterium leprae reservoir in humans, (and a few animals such as the nine-banded armadillo) transmission by inhalation (respiratory) (also by skin contact) Development of the disease through T-cell mediated response Less than 5% of people are infected in an affected group (attack rate) less than 5%, death is lower than 0.1% Incubation period…
They act through: Tyrosinase Inhibition Inhibitors of Inflammation-induced Melanogenic Response Peroxidase inhibition Product Reduction and ROS (Radical Oxygen Scavengers) Tyrosinase inhibition hydroquinone 4-hydroxyanisole 4-S-CAP and derivatives Arbutin Aloesin Azelaic Acid Kojic Acid Ellagic Acid Resveratrol Oxyeresveratrol Licorice Extract Lactic Acid Inhibitors of Inflammation Induced Melanogenic Response Chamomille Corticosteroids Gliabridin Tranexamic Acid Peroxidase…
Skin color is determined by: The type of melanin The amount of melanin in melanocytes The distribution pattern in surrounding keratinocytes The term melasma comes from Greek melas: black Etiology: The exact cause is unknown but some factors play a role Ultraviolet light (UV) genetic factors thyroid disturbances cosmetics hormonal factors (in females) Epidemiology…
Dr Christophe HSU – dermatologist. Geneva, Switzerland Medical Repigmentation treatments consist of: medical: topical (tacrolimus, pimecrolimus, topical corticosteroids…(calcipotriène, pseudocatalase, piperine)), systemic (pulse steroids…) -UV (Ultraviolet)-based therapy: Narrow Band UVB (NBUVB) is the mainstay of treatment. PUVA (Psoralen + UVA is also used but is more complicated (and less effective). Let us consider the following combination…
L’acido azelaico (AZA) è un acido dicarbossilico sintetizzato dal fungo Malassezia Furfur. L’infezione cutanea sostenuta da questo fungo è responsabile di una depigmentazione significativa e di lunga durata delle zone affette, indotta presumibilmente dall’AZA. L’AZA è un inibitore della tirosinasi, un enzima chiave coinvolto nella melaninogenesi (sintesi della melanina) all’interno dei melanociti. In caso di…
Indications: Photodermatoses Could be used as a “lifetstyle” drug to darken (tan) the skin. Afamelanotide (Melanotan) (Scenesse): induces melanin deposition (Alpha MSH (Melanocyte Stimulating Hormone) analogue) is given subcutaneously in two injections of 20mg 60 days apart. Its effect is independent from UV (Ultraviolet) light exposure or dosage It increases tolerance to artificial light Contributors:…
