Rosacea (Acne Rosacea): protective effects of Canthelicidins and the importance of the Skin Barrier (treatment tips)
- Rosacea is still a mystery with regards to etiology but it has been suggested that the Demodex mite might be associated with its presence and/or severity.
- Canthelicidines are antimicrobial peptides that protect the skin through:
- direct antimicrobial activity
- by initiating a hosp response resulting in cytokine release, inflammation, angiogenesis and reepitheliazation.
- In rosacea the synthesis of the canthelicidin protein is normal but there appears to be a post-translational abnormality with increased protease (destructive) activity of kallikrein-related peptidase 5 (KLK5). Indeed, by adding canthelicidin + KLK5 in mice, the skin becomes red.
Protecting the skin barrier
- Patients with rosacea often complain of a dry and sensitive skin accmopanied with a feeling of it burning and stinging.
- Dr F. Powell suggests avoiding products with perfume, color, or alcohol.
- As the condition tends to affect fair-skinned individuals, he recommends applying a sun block cream in the morning and a moisturizer at night.
Contributors
Dr Christophe Hsu – dermatologist. Geneva, Switzerland
Source of information: 2013 (08) – Bowers J, Unlocking the mysteries of Rosacea – Dermatology World.
