Validamycin A could inhibit the production of melanin (For Professionals)

• The authors shoe that on computer models, validamycin A induces changes in the protein structure of tyrosinase.
• Tyrosinase is an enyyme  involved in the early phases of melanin synthesis.
• Hore exactly based on targetted hydroxyl group number: HIS85, HIS244, GLU256, HIS259, and ASN260 of tyrosinase interacted with validamycin A.

Comment: the conceptual role of validomycin A in inhibiting melanin production must still be verified in vitro and in vivo.

Contributors:

Dr Christophe HSU – dermatologist. Geneva, Switzerland

Source of Information  The effect of validamycin A on tyrosinase: Inhibition kinetics and computational simulation. Z Lü,1 Y Park1,2 and J Yang2 1Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute, Tsinghua University, Jiaxing, China and 2Dermatology, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea. International Investigative Dermatology (IID) 2013 – Edinburgh, United Kingdom (UK).