How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)
How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)
- Tyrosinase is normally inactive and is produced through the transcription of the tyrosinase gene
- Glycolization (attachment of a sugar) of tyrosinase activates it. Glycolization is induced by sunlight, irritation, hormones, radicals…
- Activated tyrosinase then converst the amino acid tyrosine to melanin
- Melanin is then packaged in melanosomes which are then transfered to the surrounding keratinocytes
Contributors:
Dr Christophe HSU – dermatologist. Geneva, Switzerland
Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70e Réunion annuelle de l’AAD (American Academy of Dermatology) – San Diego, California, United States of America (USA)
Category : Comment la mélanine (pigment principal de la couleur de la peau) est t-elle produite ? - Modifie le 03.21.2012Category : How is melanin produced ? (melanin is the principal pigment giving to the skin its colour) - Modifie le 03.21.2012
