Treatments in use and their evidence in the treatment of Melasma (Chloasma) (Pregnancy Mask)

Treatments in use and their evidence in the treatment of Melasma (Chloasma) (Pregnancy Mask)

Evidence is classified from A (the best with the most evidence) to E 

A

• 4% hydroquinone + 0.05% retinoic acid (RA) + 0.01% fluocinolone acetonide

B

• 4% hydroquinone (HQ)
• 0.1% tretinoin (RA)
• 2% HQ + 0.05% RA + 0.1% dexamethasone (Modified Kligman formula) + 30-40% Glycolic Acid Peel (GA)
• 4% HQ + 5% GA
• 4% HQ + 10% GA
• 20% Azelaic Acid
• Adapalene
• 4% Kojic Acid (KA) + 5% GA

C

• 10-50% GA
• 10% GA + 2% HQ + 20-70% GA
• Jessner’s solution
• 20-30% Salicylic Acid
• 1%-5% RA
• 50% GA + 10% KA
• Q Switched Ruby Laser
• Pulsed CO2 laser + Q Switched Alexandrite Laser
• Q-Switched Alexandrite Laser
• Q-Switched Alexandrite laser + 15%-25% Trichoroacetic (TCA) peel + Jessner’s solution

D

• Erbium YAG laser

E

• Dermabrasion

Contributors:

Dr Christophe HSU – dermatologist. Geneva, Switzerland

Source of information: Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th Regional Conference of Dermatology (RCD) – Manila, Phillipines