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How the action of Cyclosporine helps in understanding anti-Il17 and anti-Il23 biologics
Saturday, December 13th, 2014When looking at psoriasis lesions, numerous T cells are present. In 1979, cyclosporine was shown to act on psoriasis as a T cell suppressor. Nevertheless, at that time but it was also shown to have an antiproliferative action on keratinocytes. Result: the biological action (cytokine inhibition) was overlooked. T cells are stimulated by antigen presenting […]
Psoriasis is enhanced by high fat diet and a possible explanation to why
Saturday, December 13th, 2014Obesity is a public health problem It is also associated with psoriasis and the Th17 cell plays a role There is a link between Body Mass Index (BMI) and the prevalence of psoriasis: however the pathophysiological reason to this link is unknown…however this study tries to give an explanation The authors used a mouse obese […]
Maintaining Youthful Skin: Perhaps a Massage is what Benchmark Research Suggests
Friday, December 12th, 2014The skin is routinely exposed to mechanical stimuli such as: stretching, contraction, compression, torsion Cyclical stretching : increases secretion of humoral factors and proteolytic enzymes by activating inflammatory signaling pathways in keratinocytes and fibroblasts induces degradation of the extracellular matrix …the response to it depends on the nature of the stimulus and its duration Methods […]
Semi permanent Make-up removal with Lasers
Friday, December 12th, 2014Semi permanent tattoos are often used to alleviate tedious daily make-up but they also, like other tattoos can become cosmetically unacceptable. Treatment: Available classical treatments include, surgery, dermabrasion but both induce scarring which is not acceptable for patients who are looking for a cosmetic procedure to correct another one. Q-Switched lasers have been tried and […]
Tuberous Sclerosis Treatment with topical Rapamycin: Beyond treating Facial Angiofibromas
Friday, December 12th, 2014Tuberous Sclerosis (TSC) is a multisytemic condition characterized by numerous skin signs (shagreen patch, ash leaf macules…). Of these, hypomelanotic macules are the most frequent sign and are present in 90% of patients with TSC. (Macules have to be 3 or more in number to fit in the diagnosis of TSC). The cause of TSC […]
Pompholyx or Dysidrosis ?
Wednesday, December 10th, 2014The Greek word of origin is: πομφολυξ = pompholyx = vesicle This term was given to what is now pemphigus by Robert Willan (a British physician, 1757-1817, the real founder of dermatology). Alibert (a French physician, 1766-1837) decided then to use this term for all bullous skin conditions originating from pemphix. This term will persist […]
Scabies: show me the mite !
Wednesday, December 10th, 2014The cause of scabies was unknown and in the early decades of the 19th century, the mite being the cause of scabies were controversial. Simon François Renucci a Corsican medical student had seen native women remove mites from people with “the itch”; it amused him to see the professors of Paris in the dark. In […]
Koebner isomorphic phenomenon: the story behind the name
Wednesday, December 10th, 2014The isomorphic phenomenon is the occurrence of the skin lesions in traumatized areas. This occurs in the following dermatoses: vitiligo, psoriasis, lichen planus, lichen nitidus, pityriasis rubra pilaris, and keratosis follicularis (Darier’s disease). It was described by Dr Heinrich Koebner (1838-1904) in 1876, a German dermatologist who trained in Paris and Vienna: he showed it […]
Syringoma: once you recognize the lesion, how do you remember to put the correct name ?
Wednesday, December 10th, 2014This term comes from the Greek word: συριγξ = surinx = canal. The word is pronounced as ” surinx”. This origin is used in other medical fields (syringomyelia, syringobulbia, syringotomy) Information on Syringoma: Syringoma develop from the excretory lining of eccrine glands They are frequent benign tumors and affect more often females with familial forms. […]
Birt-Hogg-Dubé Syndrome
Wednesday, December 10th, 2014Birt–Hogg–Dubé syndrome is a dermatological condition with a heightened risk of tumors in the kidneys and lungs. The condition is characterized by multiple benign dome-shaped tumors of the hair follicles (fibrofolliculomas), located on the face, neck and sometimes on the upper chest.Trichodiscomas and acrochordons are other lesions occuring with this syndrome Birt-Hogg-Dubé syndrome was described […]
