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Members from Nepal
Tuesday, September 3rd, 2013Kathmandu Shambhu DUTTA JOSHI MD
Menopause and the Skin (For Professionals)
Sunday, September 1st, 2013Menopause and the Skin (For Professionals) How to Take Care of Your Skin during Menopause ? The middle to late 40s is a critical period in a woman’s life. It is the age when menopause occurs. In medical literature, menopause is defined as the day a woman has been diagnosed as not having a menstrual […]
Long-lasting Hair Removal: Is it Possible ? (For Professionals)
Thursday, August 1st, 2013Long-lasting Hair Removal: Is it Possible ? (For Professionals) A lot of time and financial resources are spent by the patients for hair removal. It is often believed by the public that hair removal can be complete aften multiple treatment sessions. However this is wrong for many reasons: different lasers achieve different long term results […]
Capsaicin Receptor Reduced in Psoriasis lesions (For Professionals)
Friday, July 12th, 2013Capsaicin used topically is used in the treatment of pain following for example shingles = post herpetic neuralgia. In the following study, capsaicin receptors appear to be reduced Capsaicin receptor is also known as TRPV1 32 Patients with psoriasis (lesional) were compared with 20 with normal skin Results TRPV1 was found by RTPCR (polymerase chain […]
Treatment of melasma (chloasma) (pregnancy mask) with Creams (For Professionals)
Friday, July 12th, 2013Pathogenesis of melasma (chloasma) (pregnancy mask) remains unknown. Treatment which is effective on the epidermal component of the pigmentation acts by the following mechnisms: inhibition of melanin synthesis blockage of melanosome transker from melanocytes and keratinocytes (niacinamide). Solar eviction and photoprotection are a crucial element in the treatments. The gold standard in the treatment of […]
Acupuncture to treat Itch ? (For Professionals)
Friday, July 12th, 2013Acupuncture is known as a treatment of chronic symptoms such as pain, joint pain and the like and the following study shows interesting results in the treatment of itch (pruritus). In this in vivo study, *90 mice were treated: with a substance substance causing itch (in 30 mice) (compound 48/80) (subcutaneous injection behind the […]
Cysteamine Cream (CC): The evidence against hydroquinone and treatment of hyperpigmentation (For Professionals)
Friday, July 12th, 2013Hydroquinone is the gold standard in the treatment of hyperpigmentary disorders but there are 3. things to bear in mind: -a concentration of 4% or more is needed to be effective. -because of a higher concecntration, side effects such as exogenous ochronosis are a risk. Because of a lack of evidence pertaining to long term […]
IPCC 2014 : World Congress on Pigment Cell Research
Friday, June 21st, 2013The next world congress on skin pigmentation research will take place in 2014 in Singapore. Below is the introduction from the organizer: On behalf of the Asian Society for Pigment Cell Research (ASPCR) and Dermatological Society of Singapore (DSS), it is our pleasure to officially introduce the 22nd International Pigment Cell Conference (IPCC) to you, […]
Possible involvement of the dermis in the pathogenesis of vitiligo (For Professionals)
Thursday, June 13th, 2013Vitiligo is characterized by the functional loss of melanocytes which induces the well delineated depigmented characteristic lesions. Anomalies have been detected in: melanocytes (mitochondria…) keratinocytes (altered oxydation status in the mitochondria, vaculolization…) dermis (high level of tenascin expression which explains defective adhesion of the melanocytes) The authors have found similar defects in fibroblast cells in […]
Validamycin A could inhibit the production of melanin (For Professionals)
Thursday, June 13th, 2013The authors shoe that on computer models, validamycin A induces changes in the protein structure of tyrosinase. Tyrosinase is an enyyme involved in the early phases of melanin synthesis. Hore exactly based on targetted hydroxyl group number: HIS85, HIS244, GLU256, HIS259, and ASN260 of tyrosinase interacted with validamycin A. Comment: the conceptual role of validomycin […]
