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Metastatic lung-cell cancer treatment with Erlotinib: its cutaneous side effects and practical management advice
Saturday, August 2nd, 2014Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. Kiyohara Y, Yamazaki N, Kishi A. J Am Acad Dermatol. 2013 Sep;69(3):463-72. doi: 10.1016/j.jaad.2013.02.025. Targeted treatments against cancers have enhanced therapeutic properties as compared with older treatments. But with this also comes an array of new unwanted side-effects which are the results […]
Does Vitamin D have a protective role against Skin Cancers ?
Friday, August 1st, 2014Vitamin D in cutaneous carcinogenesis: part I and II Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. J Am Acad Dermatol. 2012 Nov;67(5):803.e1-12, quiz 815-6. doi: 10.1016/j.jaad.2012.05.044. and 827-8. doi: 10.1016/j.jaad.2012.07.022. Vitamin D has a protective effect against internal malignancies and it is suggested it could have an analogous role against […]
The Role of Tyrosine Kinases in Dermatology
Friday, August 1st, 2014Tyrosine kinases in inflammatory dermatologic disease. Paniagua RT, Fiorentino DF, Chung L, Robinson WH. J Am Acad Dermatol. 2011 Aug;65(2):389-403. doi: 10.1016/j.jaad.2010.04.026. Tyrosine kinases (TK) have been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases: Systemic Sclerosis Graft-versus-host-disease Nephrogenic Systemic Fibrosis Psoriasis Pemphigus vulgaris Bullous Pemphigoid Dermatomyositis and Systemic Lupus Erythematosus […]
Skin signs of Internal Disease: do NOT confuse Peutz Jeghers and Carney Syndromes
Friday, August 1st, 2014Carney syndrome in a patient previously considered to have Peutz-Jeghers syndrome. Richey JD, Bradish JR, Lacy SR, Warren S. J Am Acad Dermatol. 2014 Feb;70(2):e44-6. doi: 10.1016/j.jaad.2013.10.017. Some skin conditions ar associated with internal diseases. Some of these conditions can be syndromic and the existence of skin signs is associated with internal conditions Peutz-Jegher’s Syndrome […]
Metabolic Syndrome and the Skin (For Professionals)
Friday, August 1st, 2014Metabolic Syndrome and the Skin (For Professionals) Metabolic syndrome is also known as metabolic syndrome X, cardiometabolic syndrome, syndrome X, insulin resistance syndrome, Reaven’s syndrome (named for Gerald Reaven), and CHAOS (in Australia). It affects 24% of the adults in the US, with the highest prevalence being in individuals 60 through 69 years of age […]
Alcohol-induced vasculitis
Friday, August 1st, 2014Alcohol-induced vasculitis: case report and commentary. Abuabara K, Samimi S, Chu EY, Bluebond ND, James WD, Merkel PA. J Am Acad Dermatol. 2014 Feb;70(2):e42-3. doi: 10.1016/j.jaad.2013.10.014. In this interesting case report, the authors depict the story of a 26 year old woman developing erythematous macules and papules occuring a few hours after consuming an alcoholic […]
Fumaric Acid: an effective drug against psoriasis and multiple sclerosis ?
Friday, August 1st, 2014Management of psoriasis vulgaris and multiple sclerosis with fumaric acid. Gkalpakiotis S, Arenberger P, Gkalpakioti P, Meluzinova E, Chandran D, Arenbergerova M. J Am Acad Dermatol. 2014 Mar;70(3):e60-1. doi: 10.1016/j.jaad.2013.10.031. Fumaric Acid is a big thing in Germany. It is used in the management of psoriasis under the brand name Fumaderm It also seems to […]
Lasers to treat nail fungal infections (Onychomycosis)
Tuesday, July 29th, 2014Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream. Lim EH, Kim HR, Park YO, Lee Y, Seo YJ, Kim CD, Lee JH, Im M. J Am Acad Dermatol. 2014 May;70(5):918-23. doi: 10.1016/j.jaad.2014.01.893. Epub 2014 Mar 18. Nail onychomycosis is a infectioyus fungal infection which typically affects the toenails. Although present in […]
A new treatment option for Vitiligo ?
Tuesday, July 29th, 2014Reagents inducing epidermal proliferation also induce pigmentation: induction of keratinocyte proliferation as a novel strategy for the treatment of vitiligo. Wu CS, Komine M, Fujimoto S, Ohmatsu H, Kikuchi K, Tada Y, Yu HS, Ohtsuki M, Tamaki K. J Dermatol Sci. 2013 Oct;72(1):66-8. doi: 10.1016/j.jdermsci.2013.05.005. Epub 2013 Jun 18. No abstract available. Vitiligo affects 1% […]
Palmar Hyperhidrosis treatment with Botulinum Toxin: effects last longer when injections are repeated
Tuesday, July 29th, 2014Duration of efficacy increases with the repetition of botulinum toxin A injections in primary palmar hyperhidrosis: a study of 28 patients. Lecouflet M, Leux C, Fenot M, Célerier P, Maillard H. J Am Acad Dermatol. 2014 Jun;70(6):1083-7. doi: 10.1016/j.jaad.2013.12.035. Epub 2014 Mar 12. Excessive sweating of the palms or Palmar Hyperhidrosis is a psychologically devastating […]
