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Kaposi’s sarcoma: remembering the condition existed before HIV
Friday, October 24th, 2014Moriz Kaposi (1837-1902) was a Hungarian dermatologist practicing in Vienna, at the time the capital of the Austro-Hungarian Empire. He described Idiopathic Multiple Pigment Sarcoma of the skin in 1878 – now widely called Kaposi’s sarcoma. Since then it is not fully idiopathic anymore and is due to reactivation of the Human Herpesvirus type 8: […]
Pityriasis Rosea: Who named it ?
Friday, October 24th, 2014Also known as Pityriasis Rosea of Gibert, it was named by a French dermatologist in 1860. Dr Camille Gibert (1797-1866) was a student of Laurent Biett, a Swiss dermatologist (who described the collarette of Biett, a sign of secondary syphilis). Gibert also made many inoculation experiments being able to demonstrate the contagiosity of secondary syphilis. […]
Syphilis – How was the cause found ?
Friday, October 24th, 2014In 1905 , the cause of syphilis was found by two German dermatologists: a spirochaete bacteria called Treponema Pallidum When presented at a meeting of the Berlin medical society, the president, Prof Ernst Von Bergmann, cut him short with words he no doubt later regretted. “This terminates the discussion – until the next cause of […]
Hidradenitis Suppurativa (Acne Inversa): More evidence on how to treat it
Saturday, October 11th, 2014Epidemiology of Hidradenitis suppurativa (HS) also called Acne Inversa (Jemec) -Prevalence is anywhere between 0.0033% (genetic hypothesis) to 4% (self reporting in nurses) -In a big study in immigrants comparing with Spanish citizens, prevalence of HS was found to reach 0.2% up to 0.9% in Spanish citizens. prevalence is anywhere between 0.0033% (genetic hypothesis) to […]
Erythrodermic Psoriasis Treatment with Ustekinumab
Saturday, October 11th, 2014Erythrodermic psoriasis (EP) is a generalized, inflammatory erythematous dermatosis, with or without exfoliation lasting for at least 3 months involving 75% or more of the body surface Methods: In this retrospective study PASI evaluation was done at 4, 16 and 28 weeks of treatment 22 patients dosage of 45mg in 16 patients dosage of 90mg […]
Brodalumub: also effective against Nail and Scalp Psoriasis
Saturday, October 11th, 2014Brodalumab (KHK4827, also known as AMG827) is a monoclonal antibody that binds to human IL-17RA and blocks the biological activities of IL-17A, 17F, 17A/F and IL-17E It has been shown to improve plaque psoriasis and psoriatic arthritis in 12 weeks. Goal: efficacy of KHK4827 for nail nail and scalp psoriasis in Japanese patients with moderate […]
The Benefits of Sunscreens: Protective Cellular Effects from Ultraviolet A Rays
Saturday, October 11th, 2014Lipofucsin is the intracellular aggregate of oxidized proteins and lipids. It is a marker of autophagy and is stainable on immunochemistry with Sudan Black B (SBB) Ultraviolet A (UVA) damage induces DNA damage, oxidation of proteins and lipids, autophagy and subsequently apoptosis (provided exposure is long enough) In this study human cultures of fibroblasts were […]
Palmoplantar Psoriasis Treatment with Ustekinumab
Saturday, October 11th, 2014Introduction: Palmoplantar psoriasis presents as sterile pustules with hyperkeratosis, erythema, scaling and fissuring on the palms and soles Treatment is challenging. topicals don’t really work and acitretin is not always effective. Methodology: prospective study 9 patients, mean age 48 years old ustekinumab administered subcutaneously at weeks 0,4 and then every 12 weeks evaluation with PPPASI […]
PRP to treat Vitiligo ?
Saturday, October 11th, 2014PRP is an autologous platelet concentrate in a small volume of plasma obtained from high speed centrifugation of the patient blood sample Methods 26 patients with vitiligo (type and location not specified) Intradermal intralesional PRP injection was done every 2 weeks until a response was observed or improvement was seenscoring with the Vitiligo European task […]
Adalimumab vs Etanercept in Quality of Life Improvement
Saturday, October 11th, 2014Adalimumab showed a slightly higher reduction in PASI after 1 year, however it proved an equivalent efficacy to Etanercept after an extensive follow-up (up to 5 years) Contrarily to etanercept, adalimumab patients showed a progressive improvement with DLQI (84 to 77) For both groups, sustained response (PASI75 maintenance of results 60 months after initiation of […]
