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Stalin: Psoriasis and Facial Scars (from Smallpox)
jeudi, mars 12th, 2015Joseph Stalin (1878-1953; Ioseb Besarionis Dze Jugashvili; Ио́сиф Виссарио́нович Ста́лин) was the leader of the Soviet Union from the mid 1920s to his death in 1953. He had smallpox in childhood and at the age of 7 which left him badly scarred. The marks are meticulously hidden by the censorship. However they are visible in […]
Diana, princess of Wales and Rosacea (Lady Diana)
lundi, mars 2nd, 2015Lady Diana (1961-1997) is one of the most famous British personalities and was the Princess of Wales when she got married to Prince Charles in 1981. Since that time, she was closely (too closely) followed by the media until her death in Paris 16 years later. She was often described as a shy person and […]
George Orwell and Stevens-Johnson Syndrome
dimanche, février 22nd, 2015George Orwell (Eric Blair; 1903-1950) was one of the most influential of English writers in the 20th century. He wrote famous books such as 1984 (written in 1948): this masterpiece shows what totalitarian rule can be and even nowadays it displays how people can be manipulated to maintain society as it is. He was a […]
Richard Nixon and Hyperhidrosis
jeudi, février 19th, 2015Richard Nixon (1913-1994) served as the President of the United States from 1969 to 1974, when he resigned because of the Watergate scandal. It is interesting to see that most people see him as a tense figure in debates, especially the one he had against Kennedy in 1960 (which he lost): in the video above […]
Indira Gandhi (ইন্দিৰা গান্ধী) and Piebaldism
lundi, février 16th, 2015Indira Gandhi (ইন্দিৰা গান্ধী; 1917-1984) was the prime minister of India from in 1966 to 1977 (2 terms). She is the daughter of J.Nehru. She held a third term from 1980 to 1984, when she was assassinated. She has the characteristic white forelock of piebaldism: Piebaldism is inherited in an autosomal dominant way and is […]
Piebaldism: rare but all dermatologists have heard this strange term during residency
lundi, février 16th, 2015Désolé, cet article est seulement disponible en English.
Psoriasis-induced by Injected anti-TNF drugs (Paradoxical adverse, reactions): Oral non-TNF targeted therapies ?
vendredi, janvier 23rd, 2015The development of psoriasis has been observed in anti-TNF therapies for the treatment of Rheumatoid Arthritis, Ankylosing Spondylitis and Behcet’s disease. Its incidence is estimated to occur in around 5% of cases and is more frequent in females than males. It occurs 5 days to several months after the initiation of treatment in patients in […]
Ultraviolet Damage: which layer do the Cytotoxic molecules come from ?
lundi, décembre 15th, 2014Ultraviolet damage mostly comes from the generation of Reactive Oxygen Species (ROS) The enzymes responsible for the synthesis of ROS (oxygen singulets, O2. and 1O2) are Superoxide Dismutase (SOD) and Catalase. They are present in higher quantities in in the Stratum Corneum (SC) than in the lower epidermis and dermis Carbonylated Proteins (CP) are the […]
Rhododenol (Rhododendrol) – induced toxicity appears to happen at higher concentrations and the protective mechanism it triggers
lundi, décembre 15th, 2014Not all consumers developed white blotching after applying rhododendrol (rhododenol)-containing products All treatment areas didn’t necessarily develop white blotchingThe authors performed cell cultures on normal human melanocytes Results high doses (1500micromol and 3000micromol) had a cytotoxic effect apoptosis was observed at 3000micromol (through activation of caspase 3) low doses of 300-900micromol inhibited melanogenesis (downregulation of […]
Rhododenol-induced cyotoxicity: proposed mechanism of action
lundi, décembre 15th, 2014Rhododenol (Rhododendrol) is phenolic compound known to induce leucoderma. Another similar compound causing this is hydroquinone monomethyl ether The authors did a study in human melanoma B16f10 cells: Rhododenol 4, 4-hydroxyphenyl (R44HPB) 2-butanol increased The ROS (Radical Oxygen Species) H2O2 in B16f10cells The increase in the ROS H2O2 occurs when R44HPB is oxydized into quinone-tyrosinase. […]
