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Metastatic lung-cell cancer treatment with Erlotinib: its cutaneous side effects and practical management advice

samedi, août 2nd, 2014

Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. Kiyohara Y, Yamazaki N, Kishi A. J Am Acad Dermatol. 2013 Sep;69(3):463-72. doi: 10.1016/j.jaad.2013.02.025. Targeted treatments against cancers have enhanced therapeutic properties as compared with older treatments. But with this also comes an array of new unwanted side-effects which are the results […]

Does Vitamin D have a protective role against Skin Cancers ?

vendredi, août 1st, 2014

Vitamin D in cutaneous carcinogenesis: part I and II Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. J Am Acad Dermatol. 2012 Nov;67(5):803.e1-12, quiz 815-6. doi: 10.1016/j.jaad.2012.05.044.  and 827-8. doi: 10.1016/j.jaad.2012.07.022. Vitamin D has a protective effect against internal malignancies and it is suggested it could have an analogous role against […]

The Role of Tyrosine Kinases in Dermatology

vendredi, août 1st, 2014

Tyrosine kinases in inflammatory dermatologic disease. Paniagua RT, Fiorentino DF, Chung L, Robinson WH. J Am Acad Dermatol. 2011 Aug;65(2):389-403. doi: 10.1016/j.jaad.2010.04.026. Tyrosine kinases (TK) have been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases: Systemic Sclerosis Graft-versus-host-disease Nephrogenic Systemic Fibrosis Psoriasis Pemphigus vulgaris Bullous Pemphigoid Dermatomyositis and Systemic Lupus Erythematosus […]

Skin signs of Internal Disease: do NOT confuse Peutz Jeghers and Carney Syndromes

vendredi, août 1st, 2014

Carney syndrome in a patient previously considered to have Peutz-Jeghers syndrome. Richey JD, Bradish JR, Lacy SR, Warren S. J Am Acad Dermatol. 2014 Feb;70(2):e44-6. doi: 10.1016/j.jaad.2013.10.017. Some skin conditions ar associated with internal diseases. Some of these conditions can be syndromic and the existence of skin signs is associated with internal conditions Peutz-Jegher’s Syndrome […]

Syndrome métabolique et la peau (Pour les professionnels)

vendredi, août 1st, 2014

Le syndrome métabolique est également connu sous les noms suivants: le syndrome métabolique X, le syndrome cardiométabolique, le syndrome X, syndrome d’insulinorésistance, le syndrome de Reaven (du nom de Gerald Reaven), et le CHAOS (en Australie). Il affecte 24% des adultes aux Etats-Unis, avec la prévalence la plus élevée étant chez les individus 60 à […]

Alcohol-induced vasculitis

vendredi, août 1st, 2014

Alcohol-induced vasculitis: case report and commentary. Abuabara K, Samimi S, Chu EY, Bluebond ND, James WD, Merkel PA. J Am Acad Dermatol. 2014 Feb;70(2):e42-3. doi: 10.1016/j.jaad.2013.10.014. In this interesting case report, the authors depict the story of a 26 year old woman developing erythematous macules and papules occuring a few hours after consuming an alcoholic […]

Fumaric Acid: an effective drug against psoriasis and multiple sclerosis ?

vendredi, août 1st, 2014

Management of psoriasis vulgaris and multiple sclerosis with fumaric acid. Gkalpakiotis S, Arenberger P, Gkalpakioti P, Meluzinova E, Chandran D, Arenbergerova M. J Am Acad Dermatol. 2014 Mar;70(3):e60-1. doi: 10.1016/j.jaad.2013.10.031. Fumaric Acid is a big thing in Germany. It is used in the management of psoriasis under the brand name Fumaderm It also seems to […]

Lasers to treat nail fungal infections (Onychomycosis)

mardi, juillet 29th, 2014

Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream. Lim EH, Kim HR, Park YO, Lee Y, Seo YJ, Kim CD, Lee JH, Im M. J Am Acad Dermatol. 2014 May;70(5):918-23. doi: 10.1016/j.jaad.2014.01.893. Epub 2014 Mar 18. Nail onychomycosis is a infectioyus fungal infection which typically affects the toenails. Although present in […]

A new treatment option for Vitiligo ?

mardi, juillet 29th, 2014

Reagents inducing epidermal proliferation also induce pigmentation: induction of keratinocyte proliferation as a novel strategy for the treatment of vitiligo. Wu CS, Komine M, Fujimoto S, Ohmatsu H, Kikuchi K, Tada Y, Yu HS, Ohtsuki M, Tamaki K. J Dermatol Sci. 2013 Oct;72(1):66-8. doi: 10.1016/j.jdermsci.2013.05.005. Epub 2013 Jun 18. No abstract available. Vitiligo affects 1% […]

Palmar Hyperhidrosis treatment with Botulinum Toxin: effects last longer when injections are repeated

mardi, juillet 29th, 2014

Duration of efficacy increases with the repetition of botulinum toxin A injections in primary palmar hyperhidrosis: a study of 28 patients. Lecouflet M, Leux C, Fenot M, Célerier P, Maillard H. J Am Acad Dermatol. 2014 Jun;70(6):1083-7. doi: 10.1016/j.jaad.2013.12.035. Epub 2014 Mar 12. Excessive sweating of the palms or Palmar Hyperhidrosis is a psychologically devastating […]

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