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The role of blood vessels in melasma (chloasma, pregnancy mask): therapeutical implications
vendredi, août 8th, 2014Melasma (Chloasma, Pregnancy Mask) is a common pigmentary condition and although it occurs more often in females and that hormonal factors may play a role, it is still incompletely understood. Clinically: In the lesions, telangiectasia (dilated broken blood vessels), tend to be present and melasma lesions have more vascularization when compared with the perilesional skin. […]
Dengue Fever and the skin
vendredi, août 8th, 2014Up to 100 million individuals may be infected by the dengue virus each year. The virus is transmitted through arthropod bites (usually mosquitoes). Population increase makes control of mosquito population difficult as breeding sites (stagnant waters) are more numerous and less detectable (roofs…). Infection ranges from asymptomatic infection to dengue fever with/without hemorrhagic fever and […]
Psoriasis treatment: infection risk with biologics
vendredi, août 8th, 2014Newer treatments against psoriasis are targeted and are called „biologics“ as a group. However biologics can be divided into two groups, based on their molecular target. The newer ones target Il-17 and include secukinumab. The « older » ones include etanercept, infliximab and adalimumab (which bind tumor necrosis factor (TNF)) Anti-TNF medication is known to carry a […]
Cannabis to treat Acne ?
lundi, août 4th, 2014The authors sought to measure the effects of Cannabis sativa, (-)-cannabidiol (CBD) (a recreational drug) Results of the study show that: administration of CBD to cultured human sebocytes (cells that secrete sebum) and human skin organ culture inhibited the lipogenic actions of various compounds, including including testosterone. CBD suppresses sebocyte proliferation via the activation of […]
Mole checks and Melanoma detection
samedi, août 2nd, 2014Strategies for early melanoma detection: Approaches to the patient with nevi. Goodson AG, Grossman D. J Am Acad Dermatol. 2009 May;60(5):719-35; quiz 736-8. doi: 10.1016/j.jaad.2008.10.065. Mole checks are the « bread and butter » of many dermatologists. The article summarizes the concepts of practical situations that arise when checking the skin or moles for melanoma: Should we […]
Neurofibromatosis type 1 (the most common one)
samedi, août 2nd, 2014Neurofibromatosis type 1. Boyd KP, Korf BR, Theos A. J Am Acad Dermatol. 2009 Jul;61(1):1-14; quiz 15-6. doi: 10.1016/j.jaad.2008.12.051. Neurofibromatosis is also called Von Recklinghausen’s disease and affects one individual out of 3500. It is part of the phacomatoses and is inherited in an autosomal dominant fashion (mutation on chromosome 17) The review goes through […]
Melanoma: when to do a genetic screen in patients with a positive family history ?
samedi, août 2nd, 2014Selection criteria for genetic assessment of patients with familial melanoma. Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie […]
Photodynamic therapy is painful: any way around it ?
samedi, août 2nd, 2014Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. Warren CB, Karai LJ, Vidimos A, Maytin EV. J Am Acad Dermatol. 2009 Dec;61(6):1033-43. doi: 10.1016/j.jaad.2009.03.048. Photodynamic Therapy (or PDT) is a treatment involving the application of a photosensitizing substance (aminolevulinic acid (ALA), methyl-aminolevulinate MAL) for a few hours before shining a light for a few […]
Why is there itching in lymphoma and how to treat it ?
samedi, août 2nd, 2014Pruritus in cutaneous T-cell lymphoma: a review. Ahern K, Gilmore ES, Poligone B. J Am Acad Dermatol. 2012 Oct;67(4):760-8. doi: 10.1016/j.jaad.2011.12.021. Skin lymphomas (CYCL) generate a lot of itching and despite being able to target these cancers effectively, often pruritus remains. The review begins with the pathways involved in pruritus as well as the substances […]
Welcome to the Skin Planet !
samedi, août 2nd, 2014The skin microbiome: current perspectives and future challenges. Chen YE, Tsao H. J Am Acad Dermatol. 2013 Jul;69(1):143-55. doi: 10.1016/j.jaad.2013.01.016. Different bacteria, fungi and viruses live on the skin. The type of microorganisms as well as their density depends on « environmental » factors. « Tropical » areas include the skin folds such as axillae, inquinal folds… ‘Desert » areas […]
