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Oral Fumaric Acid: how long is it tolerated ?
mardi, septembre 30th, 2014Fumaric acid esters (FAE) (oral intake) are used in come countries (Germany…) in the treatment of psoriasis. It is an effective drug however its limitations lie in the fact that it can cause gastrointestinal symptoms as well as flushing In this retrospective study from Ireland done in 249 patients, demographic data, length of treatment, reasons […]
Vitiligo and Atherosclerosis
samedi, septembre 6th, 2014Vitiligo is suggested in a study by the same authors (HERE) to be associated with metabolic syndrome. High blood sugar and hypertension are risk factors and this study suggests that atherosclerosis could also be associated with vitiligo. Moreover, insulin resistance and increased homocysteine levels have already been described. Atherogenesis in its initial stages involves oxidative […]
Vitiligo and Metabolic syndrome
samedi, septembre 6th, 2014Vitiligo affects 1% of the world population and is a psychologically devastating disease especially when visible areas are affected, such as the face. Psoriasis is associated with the so-called named “metabolic syndrome” (MS): abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density cholesterol (HDL) levels) Metabolic syndrome is […]
Skin Evolutionary Theories in Early Mankind (Applied Darwinian principles) and the importance of MC1R
vendredi, septembre 5th, 2014Characteristics of the skin in the direct predecessor of mankind (homo (neandertalis…)): functional hairlessness increased density of eccrine glands persistence of hair follicular units 1 million years ago, the predecessors of mankind, the skin (in addition to becoming hairless became) darkly pigmented and MC1R became invariant It was been shown that in that skin; High […]
Vitiligo evolving badly: the « Confetti-like macule sign »
vendredi, septembre 5th, 2014The evolution of vitiligo is difficult to predict and follicular regimentation is a sign of positive evolution ov vitiligo often, when undergoing treatment. Conversely there is apparently a sign of unfavorable of evolution: confetti-like marks These are small irregular (confetti shaped) macules on the periphery of preexisting vitiligo lesions in patients with extensive vitiligo vulgaris […]
Getting White Hair Early: Risk Factors
vendredi, septembre 5th, 2014Premature Hair Greying (PMG) is a source of low self esteem. In this study from South Korea the authors sought to investigate risk factors for early white hair. In this cross-sectional study, questionnaires were given to men under the age of 30 This involved a total of 6390 males, after a pilot-study enrolling 1069 subjects […]
The role of melanocytes in skin pigmentation and how they are regulated
samedi, août 23rd, 2014In mammals, the melanocyte and melanin are responsible hair color and protection of the skin from ultraviolet light (UV). In their development, melanocytes initally derived from neural crest cells, migrate to the basal layer of the epidermis and hair follicles. The migration and proliferation of these cells and the synthesis of melanin is a regulated […]
Phototherapy: How does it work ?
samedi, août 23rd, 2014Phototherapy is widely used in dermatology for the treatment of various skin conditions such as psoriasis, eczema, vitiligo, scleroderma and the list goes on and on. Different light spectrums, such as ultraviolet A (UVA), UVB, narrow band UVB…are used. Although poorly understood, suggested mechanisms are: Immune suppression (especially for UV): through immunoregulation by Langerhans cells, […]
Photophoresis-induced Red Blood Cell Disorders
vendredi, août 22nd, 2014Extracorporeal photophoresis (ECP) has been used for the treatment of cutaneous T cell lymphoma, including graft versus host disease (GVHD), solid organ transplant rejection, scleroderma, atopic dermatitis, epidermolysis bullosa acquisita, lichen planus, lupus erythematosus, pemphigus vulgaris, Crohn disease, and type 1 diabetes. This article is a casease report of a rare autoimmune hemolytic anemia called […]
Pemphigus Vulgaris: Defining Disease States And Treatment Outcomes
jeudi, août 21st, 2014Pemphigus vulgaris is an autoimmune bullous skin disease which is divided into pemphigus vulgaris (disorder of desmoglein 3) and Pemphigus foliaceus (desmoglein 1, endemic form=fogo selvagem). This consensus has all its sense especially for pemphigus vulgaris as it is a non curable disease. Therefore it is very important to be able to classify disease states, […]
