Articles
Neurofibromatosis type 1 (the most common one)
samedi, août 2nd, 2014Neurofibromatosis type 1. Boyd KP, Korf BR, Theos A. J Am Acad Dermatol. 2009 Jul;61(1):1-14; quiz 15-6. doi: 10.1016/j.jaad.2008.12.051. Neurofibromatosis is also called Von Recklinghausen’s disease and affects one individual out of 3500. It is part of the phacomatoses and is inherited in an autosomal dominant fashion (mutation on chromosome 17) The review goes through […]
Melanoma: when to do a genetic screen in patients with a positive family history ?
samedi, août 2nd, 2014Selection criteria for genetic assessment of patients with familial melanoma. Leachman SA, Carucci J, Kohlmann W, Banks KC, Asgari MM, Bergman W, Bianchi-Scarrà G, Brentnall T, Bressac-de Paillerets B, Bruno W, Curiel-Lewandrowski C, de Snoo FA, Debniak T, Demierre MF, Elder D, Goldstein AM, Grant-Kels J, Halpern AC, Ingvar C, Kefford RF, Lang J, MacKie […]
Photodynamic therapy is painful: any way around it ?
samedi, août 2nd, 2014Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. Warren CB, Karai LJ, Vidimos A, Maytin EV. J Am Acad Dermatol. 2009 Dec;61(6):1033-43. doi: 10.1016/j.jaad.2009.03.048. Photodynamic Therapy (or PDT) is a treatment involving the application of a photosensitizing substance (aminolevulinic acid (ALA), methyl-aminolevulinate MAL) for a few hours before shining a light for a few […]
Why is there itching in lymphoma and how to treat it ?
samedi, août 2nd, 2014Pruritus in cutaneous T-cell lymphoma: a review. Ahern K, Gilmore ES, Poligone B. J Am Acad Dermatol. 2012 Oct;67(4):760-8. doi: 10.1016/j.jaad.2011.12.021. Skin lymphomas (CYCL) generate a lot of itching and despite being able to target these cancers effectively, often pruritus remains. The review begins with the pathways involved in pruritus as well as the substances […]
Welcome to the Skin Planet !
samedi, août 2nd, 2014The skin microbiome: current perspectives and future challenges. Chen YE, Tsao H. J Am Acad Dermatol. 2013 Jul;69(1):143-55. doi: 10.1016/j.jaad.2013.01.016. Different bacteria, fungi and viruses live on the skin. The type of microorganisms as well as their density depends on « environmental » factors. « Tropical » areas include the skin folds such as axillae, inquinal folds… ‘Desert » areas […]
Metastatic lung-cell cancer treatment with Erlotinib: its cutaneous side effects and practical management advice
samedi, août 2nd, 2014Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. Kiyohara Y, Yamazaki N, Kishi A. J Am Acad Dermatol. 2013 Sep;69(3):463-72. doi: 10.1016/j.jaad.2013.02.025. Targeted treatments against cancers have enhanced therapeutic properties as compared with older treatments. But with this also comes an array of new unwanted side-effects which are the results […]
Does Vitamin D have a protective role against Skin Cancers ?
vendredi, août 1st, 2014Vitamin D in cutaneous carcinogenesis: part I and II Tang JY, Fu T, Lau C, Oh DH, Bikle DD, Asgari MM. J Am Acad Dermatol. 2012 Nov;67(5):803.e1-12, quiz 815-6. doi: 10.1016/j.jaad.2012.05.044. and 827-8. doi: 10.1016/j.jaad.2012.07.022. Vitamin D has a protective effect against internal malignancies and it is suggested it could have an analogous role against […]
The Role of Tyrosine Kinases in Dermatology
vendredi, août 1st, 2014Tyrosine kinases in inflammatory dermatologic disease. Paniagua RT, Fiorentino DF, Chung L, Robinson WH. J Am Acad Dermatol. 2011 Aug;65(2):389-403. doi: 10.1016/j.jaad.2010.04.026. Tyrosine kinases (TK) have been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases: Systemic Sclerosis Graft-versus-host-disease Nephrogenic Systemic Fibrosis Psoriasis Pemphigus vulgaris Bullous Pemphigoid Dermatomyositis and Systemic Lupus Erythematosus […]
Skin signs of Internal Disease: do NOT confuse Peutz Jeghers and Carney Syndromes
vendredi, août 1st, 2014Carney syndrome in a patient previously considered to have Peutz-Jeghers syndrome. Richey JD, Bradish JR, Lacy SR, Warren S. J Am Acad Dermatol. 2014 Feb;70(2):e44-6. doi: 10.1016/j.jaad.2013.10.017. Some skin conditions ar associated with internal diseases. Some of these conditions can be syndromic and the existence of skin signs is associated with internal conditions Peutz-Jegher’s Syndrome […]
Alcohol-induced vasculitis
vendredi, août 1st, 2014Alcohol-induced vasculitis: case report and commentary. Abuabara K, Samimi S, Chu EY, Bluebond ND, James WD, Merkel PA. J Am Acad Dermatol. 2014 Feb;70(2):e42-3. doi: 10.1016/j.jaad.2013.10.014. In this interesting case report, the authors depict the story of a 26 year old woman developing erythematous macules and papules occuring a few hours after consuming an alcoholic […]
