Skin Evolutionary Theories in Early Mankind (Applied Darwinian principles) and the importance of MC1R

Characteristics of the skin in the direct predecessor of mankind (homo (neandertalis…)): functional hairlessness increased density of eccrine glands persistence of hair follicular units 1 million years ago, the predecessors of mankind, the skin (in addition to becoming hairless became) darkly pigmented and MC1R became invariant It was been shown that in that skin; High…

Vitiligo evolving badly: the "Confetti-like macule sign"

The evolution of vitiligo is difficult to predict and follicular regimentation is a sign of positive evolution ov vitiligo often, when undergoing treatment. Conversely there is apparently a sign of unfavorable of evolution: confetti-like marks These are small irregular (confetti shaped) macules on the periphery of preexisting vitiligo lesions in patients with extensive vitiligo vulgaris…