In mammals, the melanocyte and melanin are responsible hair color and protection of the skin from ultraviolet light (UV). In their development, melanocytes initally derived from neural crest cells, migrate to the basal layer of the epidermis and hair follicles. The migration and proliferation of these cells and the synthesis of melanin is a regulated…
Phototherapy is widely used in dermatology for the treatment of various skin conditions such as psoriasis, eczema, vitiligo, scleroderma and the list goes on and on. Different light spectrums, such as ultraviolet A (UVA), UVB, narrow band UVB…are used. Although poorly understood, suggested mechanisms are: Immune suppression (especially for UV): through immunoregulation by Langerhans cells,…
Extracorporeal photophoresis (ECP) has been used for the treatment of cutaneous T cell lymphoma, including graft versus host disease (GVHD), solid organ transplant rejection, scleroderma, atopic dermatitis, epidermolysis bullosa acquisita, lichen planus, lupus erythematosus, pemphigus vulgaris, Crohn disease, and type 1 diabetes. This article is a casease report of a rare autoimmune hemolytic anemia called…
Pemphigus vulgaris is an autoimmune bullous skin disease which is divided into pemphigus vulgaris (disorder of desmoglein 3) and Pemphigus foliaceus (desmoglein 1, endemic form=fogo selvagem). This consensus has all its sense especially for pemphigus vulgaris as it is a non curable disease. Therefore it is very important to be able to classify disease states,…
It is not exactly a secret that when things go wrong in lymphocytes, which are so important in immunosurveillance, there are consequences on the organism’s defense against external agents. Conversely, as this review shows, infectious agents might be able to regulate T lymphocytes. Soft cell tumors affect lymphonodes, but they can initially affect the skin…
Beware when looking at an hyperkeratosis lesion on the nipple and discount it as being a simple eczematous rash. Not only can Paget’s disease be missed but also other lesions such as apocrine tumors such as Syringocystadenoma papilliferum as reported in this case report. For full access to the free article in the Journal of…
Sweet’s syndrome is a neutrophilic dermatosis of unknown etiology which presents as « mountain-like » papulesand is often accompanied by systemic symptoms such as fever, myalgia, asthenia and malaise. The cause is often not found but includes: infections (respiratory, gastrointestinal), autoimmune conditions (lupus, rheumatoid, arthritis), vaccination, neoplasia (solid and non solid), drugs (NSAIDS, cotrimoxazole, antiiotics, carbamazepine…) pregnancy,…
Vancomycin is an antibiotic used for intravenous treatment of bacterial infections, particularly hospital (nosocomial) acquired ones such as with Methicillin Resistant Staphlococcus Aureus (MRSA) infections, which are resistant to penicillin. Vancomycin is known to create neutropenia but the following case report reports the occurrence of a neutrophilic dermatosis mimicking cryptococcus. No organism was found and…
Basal Cell Carcinoma is know to be physiopathologically generated by an activation of the sonic hedgehog pathway. Vismodegib is an inhibitor of smoothened (SMO*) and is proposed as an adjuvant therapy before radiotherapy here after a successful case report: it was used as a therapy for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)…
Lichen Striatus is a dermatosis along Blaschko lines and its etiology is unknown. It would occurr secondarily to a cytotoxic reaction because of a stimulation of the immune system. The authors report lichen striatus occurring after etanercept (50mg/d) in a 70 year old patient treated for rheumatoid arthritis. For full access to the free article…
