Nouvelles thérapies ciblées pour le traitement de maladies de la peau avec des anomalies génétiques

Tuberous Sclerosis Topical Rapamycin could be used to treat facial angiofibromas (“Adenoma Sebaceum”) (link) (Archives of Dermatology, 2010) Neurofibromatosis (Recklinghausen’s Disease) Mast cells play an important role The c-Kit receptor on mast cells is stimulated by mediators that are liberated by Schwann cells The activation of mast cells then induces the liberation of maediators that…

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Nouvelles thérapies ciblées pour le traitement de maladies de la peau avec des anomalies génétiques

Tuberous Sclerosis Topical Rapamycin could be used to treat facial angiofibromas (“Adenoma Sebaceum”) (link) (Archives of Dermatology, 2010) Neurofibromatosis (Recklinghausen’s Disease) Mast cells play an important role The c-Kit receptor on mast cells is stimulated by mediators that are liberated by Schwann cells The activation of mast cells then induces the liberation of maediators that…

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Névus de Hori (Névus d’Ota bilatéral acquis)

Introduction It is a skin disorder which concerns mainly Asians Clinically, Hori’s Nevus can coexist with melasma (chloasma, pregnancy mask) and or solar lentigos. It can be difficult to distinguish them*. *But it is important to distinguish them as Hori’s nevus responds well to the Nd-YAG 1064nm laser. However, solar lentigos (lentigenes) respond well to…

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Lignin Peroxidase: un cosmétique dans le traitement de l’hyperpigmentation

Hyperpigmentation disorders are diverse and treatment success is highly variable. However it is important to note that the more superficial the pigmentation is, the better the response to treatment is likely to be high. Here below is a proposed skin lightening agent: lignin peroxidase It is derived from a fungus: phanerochaete chrysosporium It was studied…

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L’Hydroquinone pour traiter les lésions post-inflammatoires de l’acné

Hydroquinone Therapy for Post-inflammatory Hyperpigmentation Secondary to Acne: Not Just Prescribable by Dermatologists. Chandra M, Levitt J, Pensabene CA. Acta Derm Venereol. 2011 Oct 17. doi: 10.2340/00015555-1225. In darker skin phototypes (Fitzpatrick IV and above), post inflammatory hyperpigmentation (PIH) following active inflammatory acne lesions (papules, pustules) is an issue and very common cause of emotional…

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Manifestations cutanées de l’anaphylaxie (choc anaphylactique) (Pour les professionnels)

Anaphylaxis is a severe form of allergic reaction to certain substances such as food, drugs, insect stings and others. These substances serve as stimuli which attract certain antibodies in the body known as IgE antibodies. These IgE antibodies are bound to mast cells in the skin. These mast cells release chemicals that are disseminated in…

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Manifestations cutanées de l’anaphylaxie (choc anaphylactique) (Pour les professionnels)

Anaphylaxis is a severe form of allergic reaction to certain substances such as food, drugs, insect stings and others. These substances serve as stimuli which attract certain antibodies in the body known as IgE antibodies. These IgE antibodies are bound to mast cells in the skin. These mast cells release chemicals that are disseminated in…

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Utilisation de l’Hydroquinone et Ochronose

Rule No: 1 Recognize melasma (chloasma, pregnancy mask) Rule out the differential diagnoses: lichen planus pigmentosus (darker skin patients (Indians), pigmentation is often seen behind the ears) Hori’s Nevus Drug-induced hyperpigmentation ochronosis Rule No: 2 If the patient reports worsening of melasma with hydroquinone use, consider seriouslsy the diagnosis of ochronosis: Stage 3 ochronosis is…

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Utilisation de l’Hydroquinone et Ochronose

Rule No: 1 Recognize melasma (chloasma, pregnancy mask) Rule out the differential diagnoses: lichen planus pigmentosus (darker skin patients (Indians), pigmentation is often seen behind the ears) Hori’s Nevus Drug-induced hyperpigmentation ochronosis Rule No: 2 If the patient reports worsening of melasma with hydroquinone use, consider seriouslsy the diagnosis of ochronosis: Stage 3 ochronosis is…

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Troubles Hyperpigmentaires chez les enfants

Pigmentary disorders are frequent in children and can result in significant psychosocial problems. Hyperpigmentary disorders can be classified into melanocytes problems (epidermal, dermal) and neurocutaneous disorders presenting with pigmentation problems. Giant congenital nevus carries a low risk of malignant transformation (melanoma) but it is important to exclude cutaneous neuromelanosis in high risk patients. Malignant lentiginosis…

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