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The Role of Tyrosine Kinases in Dermatology

Tyrosine kinases in inflammatory dermatologic disease. Paniagua RT, Fiorentino DF, Chung L, Robinson WH. J Am Acad Dermatol. 2011 Aug;65(2):389-403. doi: 10.1016/j.jaad.2010.04.026. Tyrosine kinases (TK) have been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases: Systemic Sclerosis Graft-versus-host-disease Nephrogenic Systemic Fibrosis Psoriasis Pemphigus vulgaris Bullous Pemphigoid Dermatomyositis and Systemic Lupus Erythematosus…

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Skin signs of Internal Disease: do NOT confuse Peutz Jeghers and Carney Syndromes

Carney syndrome in a patient previously considered to have Peutz-Jeghers syndrome. Richey JD, Bradish JR, Lacy SR, Warren S. J Am Acad Dermatol. 2014 Feb;70(2):e44-6. doi: 10.1016/j.jaad.2013.10.017. Some skin conditions ar associated with internal diseases. Some of these conditions can be syndromic and the existence of skin signs is associated with internal conditions Peutz-Jegher’s Syndrome…

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Syndrome métabolique et la peau (Pour les professionnels)

Metabolic Syndrome and the Skin (For Professionals) Metabolic syndrome is also known as metabolic syndrome X, cardiometabolic syndrome, syndrome X, insulin resistance syndrome, Reaven’s syndrome (named for Gerald Reaven), and CHAOS (in Australia). It affects 24% of the adults in the US, with the highest prevalence being in individuals 60 through 69 years of age…

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Dermatologie dans les maladies systémiques

Alcohol-induced vasculitis

Alcohol-induced vasculitis: case report and commentary. Abuabara K, Samimi S, Chu EY, Bluebond ND, James WD, Merkel PA. J Am Acad Dermatol. 2014 Feb;70(2):e42-3. doi: 10.1016/j.jaad.2013.10.014. In this interesting case report, the authors depict the story of a 26 year old woman developing erythematous macules and papules occuring a few hours after consuming an alcoholic…

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Fumaric Acid: an effective drug against psoriasis and multiple sclerosis ?

Management of psoriasis vulgaris and multiple sclerosis with fumaric acid. Gkalpakiotis S, Arenberger P, Gkalpakioti P, Meluzinova E, Chandran D, Arenbergerova M. J Am Acad Dermatol. 2014 Mar;70(3):e60-1. doi: 10.1016/j.jaad.2013.10.031. Fumaric Acid is a big thing in Germany. It is used in the management of psoriasis under the brand name Fumaderm It also seems to…

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A new treatment option for Vitiligo ?

Reagents inducing epidermal proliferation also induce pigmentation: induction of keratinocyte proliferation as a novel strategy for the treatment of vitiligo. Wu CS, Komine M, Fujimoto S, Ohmatsu H, Kikuchi K, Tada Y, Yu HS, Ohtsuki M, Tamaki K. J Dermatol Sci. 2013 Oct;72(1):66-8. doi: 10.1016/j.jdermsci.2013.05.005. Epub 2013 Jun 18. No abstract available. Vitiligo affects 1%…

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Palmar Hyperhidrosis treatment with Botulinum Toxin: effects last longer when injections are repeated

Duration of efficacy increases with the repetition of botulinum toxin A injections in primary palmar hyperhidrosis: a study of 28 patients. Lecouflet M, Leux C, Fenot M, Célerier P, Maillard H. J Am Acad Dermatol. 2014 Jun;70(6):1083-7. doi: 10.1016/j.jaad.2013.12.035. Epub 2014 Mar 12. Excessive sweating of the palms or Palmar Hyperhidrosis is a psychologically devastating…

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Diabetes Mellitus: Severe Psoriasis and some Drugs heighten the Risk of having it

Increased risk of diabetes mellitus in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study. Lee MS, Lin RY, Lai MS. J Am Acad Dermatol. 2014 Apr;70(4):691-8. doi: 10.1016/j.jaad.2013.11.023. Epub 2014 Jan 9. Introduction: Diabetes Mellitus doesn’t necessarily occur in patients with psoriasis but some clinical caracteristics as well…

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Androgenetic Alopecia Treatment with Another Inhibitor Of Dihydrotestosterone

A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. Gubelin Harcha W, Barboza Martínez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, Barnes A, Ferron-Brady G, Chetty D. J Am Acad Dermatol. 2014 Mar;70(3):489-498.e3.…

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