Adenoma Sebaceum in Tuberous Sclerosis: A misnomer !

Adenoma Sebaceum refers to lesions on the face described in 1890 by the British dermatologist Dr John James Pringle (1855-1922). Adenoma Sebaceum is a misnomer, the lesions are actually angiofibromas – which is closer to Koenen’s tumors which are peringual fibromas. The facial lesions are neither adenomas, nor sebaceous in origin. Multiple “real” sebacous adenomas…

Topical steroids in dermatology: the story behind it

The use of steroids in dermatology was initiated by two American New-York based dermatologists: Marion Sulzberger and Victor Witten. Topical steroids: early topical preparations containing cortisone acetate were surprisingly ineffective HYDROcortisone acetate was made available (“Compound F” by Merck): It was combined 25mg/g with an ointment base…and became moderately effective initially for Atopic Dermatitis. Results…