Rhododenol is also called 4-(4-hydroxyphenyl)-2-butanol. It is manufactured by Kanebo cosmetics and has been on the market since 2008. It is naturally produced and has been approved for the management of pigmentary problems (Melasma, Sun spots, Lentigo…) It is a phenolic compound therefore it is potentially melanocytoxic. It acts by reducing the activity of tyrosinase…
Kojic acid It is a fungal metabolite which inhibits the enzyme tyrosinase. It binds to copper which becomes unusable by melanocytes. It is used at a concentration of 1% Its therapeutical effets are weak to moderate. Contributors: Dr Christophe HSU – dermatologist. Geneva, Switzerland Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70th Annual Meeting of…
Kojic acid It is a fungal metabolite which inhibits the enzyme tyrosinase. It binds to copper which becomes unusable by melanocytes. It is used at a concentration of 1% Its therapeutical effets are weak to moderate. Contributors: Dr Christophe HSU – dermatologist. Geneva, Switzerland Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70th Annual Meeting of…
Hydroquinone (HQ) Mechanism of action: hydroquinone inhibits activated tyrosinase activity (therefore it does not act on normal skin). A word on available concentrations: 2%: often ineffective 3-5%: good bleaching agent 6-10%: higher concentrations can cause irritation Side effects: Contact dermatitis (Both Allergic and Irritant) Nail Discoloration Exogenous Ochrnosis can rarely occur in dark skin individuals…
Hydroquinone (HQ) Mechanism of action: hydroquinone inhibits activated tyrosinase activity (therefore it does not act on normal skin). A word on available concentrations: 2%: often ineffective 3-5%: good bleaching agent 6-10%: higher concentrations can cause irritation Side effects: Contact dermatitis (Both Allergic and Irritant) Nail Discoloration Exogenous Ochrnosis can rarely occur in dark skin individuals…
L-ascorbic acid (Vitamin C) Is an antioxidant Is used in the treatment of disorders of pigmentation including melasma (chloasma) (pregnancy mask) Alters the color of melanin from jet black to light tan Unstable as quickly oxidized Bibliography: Katsambas A (Conflicts of Interest: Abbott, Janssen-Cilag, Leo Pharma, Merck, Schering-Plough). Melasma: Pathogenesis and Treatment. 70e Réunion annuelle…
L-ascorbic acid (Vitamin C) Is an antioxidant Is used in the treatment of disorders of pigmentation including melasma (chloasma) (pregnancy mask) Alters the color of melanin from jet black to light tan Unstable as quickly oxidized Bibliography: Katsambas A (Conflicts of Interest: Abbott, Janssen-Cilag, Leo Pharma, Merck, Schering-Plough). Melasma: Pathogenesis and Treatment. 70e Réunion annuelle…
New Depigmenting substances: N-acetyl glucosamine Artocarpanone 4-n-butylresorcinol (rucinol) Ursolic Acid Anthraquinones Cinnamic Acid Macelignan Gallic Acid Glycine Isopanduratin A and 4-Hydroxypanduratin A Kurarinol, Kurarinidol and Trifolirhizin Pycnogenol 8% topical indomethacin cream Selina dien-8-one Taxifolin DeoxyArbutin and its second generation derivatives Hydroperoxy Traxastane t; type Triterpene Piceatannol Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th…
New Depigmenting substances: N-acetyl glucosamine Artocarpanone 4-n-butylresorcinol (rucinol) Ursolic Acid Anthraquinones Cinnamic Acid Macelignan Gallic Acid Glycine Isopanduratin A and 4-Hydroxypanduratin A Kurarinol, Kurarinidol and Trifolirhizin Pycnogenol 8% topical indomethacin cream Selina dien-8-one Taxifolin DeoxyArbutin and its second generation derivatives Hydroperoxy Traxastane t; type Triterpene Piceatannol Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th…
They act through: Tyrosinase Inhibition Inhibitors of Inflammation-induced Melanogenic Response Peroxidase inhibition Product Reduction and ROS (Radical Oxygen Scavengers) Tyrosinase inhibition hydroquinone 4-hydroxyanisole 4-S-CAP and derivatives Arbutin Aloesin Azelaic Acid Kojic Acid Ellagic Acid Resveratrol Oxyeresveratrol Licorice Extract Lactic Acid Inhibitors of Inflammation Induced Melanogenic Response Chamomille Corticosteroids Gliabridin Tranexamic Acid Peroxidase…
