Apremilast for atopic dermatitis: reversing interleukin-4 dysregulation on primary human keratinocytes (Poster) Mohan GC et al. AAD 2015 Annual Meeting, San Francisco CA – United States INTRODUCTION Apremilast (Otezla) is an oral treatment for plaque psoriasis. It is a small molecule which acts through inhibition of phosphodiesterase 4 (PDE4) (In atopic dermatitis (AD), there is…
Cost per responder of apremilast versus etanercept, adalimumab, and ustekinumab in Patients with moderate to severe psoriasis (Poster) Feldman SR et al AAD 2015 Annual Meeting, San Francisco CA – United States With the injected biologics treatment for psoriasis and the newer oral “small molecules” for the treatment of psoriasis the authors found it useful…
Introduction The drug is called apremilast under the brand name Otezla It is indicated in patients with moderate-to-severe plaque psoriasis Studied since 2004 in clinical trials in over 3500 patients Is it effective ? In a randomized-control trial 1257 with moderate-to-severe psoriasis and evaluated after 16 weeks (after a week of progressively increasing dosage) The…
The development of psoriasis has been observed in anti-TNF therapies for the treatment of Rheumatoid Arthritis, Ankylosing Spondylitis and Behcet’s disease. Its incidence is estimated to occur in around 5% of cases and is more frequent in females than males. It occurs 5 days to several months after the initiation of treatment in patients in…
Ultraviolet damage mostly comes from the generation of Reactive Oxygen Species (ROS) The enzymes responsible for the synthesis of ROS (oxygen singulets, O2. and 1O2) are Superoxide Dismutase (SOD) and Catalase. They are present in higher quantities in in the Stratum Corneum (SC) than in the lower epidermis and dermis Carbonylated Proteins (CP) are the…
Not all consumers developed white blotching after applying rhododendrol (rhododenol)-containing products All treatment areas didn’t necessarily develop white blotchingThe authors performed cell cultures on normal human melanocytes Results high doses (1500micromol and 3000micromol) had a cytotoxic effect apoptosis was observed at 3000micromol (through activation of caspase 3) low doses of 300-900micromol inhibited melanogenesis (downregulation of…
Rhododenol (Rhododendrol) is phenolic compound known to induce leucoderma. Another similar compound causing this is hydroquinone monomethyl ether The authors did a study in human melanoma B16f10 cells: Rhododenol 4, 4-hydroxyphenyl (R44HPB) 2-butanol increased The ROS (Radical Oxygen Species) H2O2 in B16f10cells The increase in the ROS H2O2 occurs when R44HPB is oxydized into quinone-tyrosinase.…
This study suggests an objective way to follow-up of rhododenol-induced vitiligo by skin absorption spectrum analysis A word on Rhododenol (Rhododendrol): Rhododendrol (Rhododenol) is is derived from the white birch tree it inhibits tyrosinase activity and melanin synthesis Vitiligo-like lesions were observed and in march 2014, 14000 cases were reported in Japan alone In this…
Rhododendrol (Rhododenol, RD) created a big problem in Japan, when 14000 induced cases of vitiligo-like lesions were reported. It is known that Rhodoendol is cytoxic against melanocytes in a Tyrosinase dependent way cytotoxicity The authors suggest a new mouse model for the study of this effect: hk14-scf/HRM Tg Mice become albino (fully depigmented) through suppression…
The phenolic compound phloretin: is a member of dihydrochalcones is found in apples and apple juice Phloretin 3,3 disulfonate (P33D) is obtained after its sulfonation with sulfuric acid Pure concentrated Phloretin sodium sulfonate was added to Human Cell cultures which were irradiated with UVB 20 mJ/cm2 Results show that reduced amounts of P33D were found…
