Acide isonicotinique d’hydrazide (isoniazide) comme nouvel agent dépigmentant

Topical isonicotinic acid hydrazide (isoniazid) as a new skin depigmenting compound Ahmadi Sara.1, Pourahmadi M.1, Aslani F.S.2, Kasraee B.3 1Jahrom University of Medical Sciences, Dept. of Dermatology, Jahrom, Iran, 2Shiraz University of Medical Sciences, Dept. of Pathology, Shiraz, Iran, 3Scientis Pharma, Research Department, Geneva, Switzerland INTRODUCTION & OBJECTIVES: Isonicotinic acid hydrazide (isoniazid) is the most…

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Melasma (Chloasma, Masque de grossesse), Vaisseaux sanguins et l’utilité du laser vasculaire

Melasma lesions show an increase in blood vessels (Chloasma, Pregnancy Mask) lesions when compared with perilesional skin (Kang HY 2010) Decrease in Melasma pigmentation with topical cream (triple combination cream with hydroquinone, a topical steroid and tretinoin) combined with PDL (Pulse-dye laser) (lien). Contributeurs Dr Christophe HSU – dermatologist. Geneva, Switzerland Source of Information: SY…

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Melasma (Chloasma, Masque de grossesse), Vaisseaux sanguins et l’utilité du laser vasculaire

Melasma lesions show an increase in blood vessels (Chloasma, Pregnancy Mask) lesions when compared with perilesional skin (Kang HY 2010) Decrease in Melasma pigmentation with topical cream (triple combination cream with hydroquinone, a topical steroid and tretinoin) combined with PDL (Pulse-dye laser) (lien). Contributeurs Dr Christophe HSU – dermatologist. Geneva, Switzerland Source of Information: SY…

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Nouvelles thérapies ciblées pour le traitement de maladies de la peau avec des anomalies génétiques

Tuberous Sclerosis Topical Rapamycin could be used to treat facial angiofibromas (“Adenoma Sebaceum”) (link) (Archives of Dermatology, 2010) Neurofibromatosis (Recklinghausen’s Disease) Mast cells play an important role The c-Kit receptor on mast cells is stimulated by mediators that are liberated by Schwann cells The activation of mast cells then induces the liberation of maediators that…

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Nouvelles thérapies ciblées pour le traitement de maladies de la peau avec des anomalies génétiques

Tuberous Sclerosis Topical Rapamycin could be used to treat facial angiofibromas (“Adenoma Sebaceum”) (link) (Archives of Dermatology, 2010) Neurofibromatosis (Recklinghausen’s Disease) Mast cells play an important role The c-Kit receptor on mast cells is stimulated by mediators that are liberated by Schwann cells The activation of mast cells then induces the liberation of maediators that…

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Névus de Hori (Névus d’Ota bilatéral acquis)

Introduction It is a skin disorder which concerns mainly Asians Clinically, Hori’s Nevus can coexist with melasma (chloasma, pregnancy mask) and or solar lentigos. It can be difficult to distinguish them*. *But it is important to distinguish them as Hori’s nevus responds well to the Nd-YAG 1064nm laser. However, solar lentigos (lentigenes) respond well to…

Maladies de peau, Notes de congrès/conférences

Lignin Peroxidase: un cosmétique dans le traitement de l’hyperpigmentation

Hyperpigmentation disorders are diverse and treatment success is highly variable. However it is important to note that the more superficial the pigmentation is, the better the response to treatment is likely to be high. Here below is a proposed skin lightening agent: lignin peroxidase It is derived from a fungus: phanerochaete chrysosporium It was studied…

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Utilisation de l’Hydroquinone et Ochronose

Rule No: 1 Recognize melasma (chloasma, pregnancy mask) Rule out the differential diagnoses: lichen planus pigmentosus (darker skin patients (Indians), pigmentation is often seen behind the ears) Hori’s Nevus Drug-induced hyperpigmentation ochronosis Rule No: 2 If the patient reports worsening of melasma with hydroquinone use, consider seriouslsy the diagnosis of ochronosis: Stage 3 ochronosis is…

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Utilisation de l’Hydroquinone et Ochronose

Rule No: 1 Recognize melasma (chloasma, pregnancy mask) Rule out the differential diagnoses: lichen planus pigmentosus (darker skin patients (Indians), pigmentation is often seen behind the ears) Hori’s Nevus Drug-induced hyperpigmentation ochronosis Rule No: 2 If the patient reports worsening of melasma with hydroquinone use, consider seriouslsy the diagnosis of ochronosis: Stage 3 ochronosis is…

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Troubles Hyperpigmentaires chez les enfants

Pigmentary disorders are frequent in children and can result in significant psychosocial problems. Hyperpigmentary disorders can be classified into melanocytes problems (epidermal, dermal) and neurocutaneous disorders presenting with pigmentation problems. Giant congenital nevus carries a low risk of malignant transformation (melanoma) but it is important to exclude cutaneous neuromelanosis in high risk patients. Malignant lentiginosis…

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