Atopic Dermatitis: a Short Summary
- Ciclosporine works by calcineurin inhibition by intefering with T-lymphocyte transcription of IL-2.
- The long-term use of ciclosporine can be limited by the two major side effects of renal toxicity and hypertension.
- More recently it has been used in a short term approach via intermittent three- to four-month intervals, either to obtain a quick response before transitioning to another agent, or to control a flare in a patient on stable systemic therapy.
- Dosing is usually started at 4-5 mg/kg/d and then tapering as clearance is achieved.
Kalb. R 2013 (07) – Kalb. R. Treatment of Psoriasis in the Age of Biologics – 25th Annual Scientific Meeting of the Dermatological Society of Singapore (DSS) – Singapore
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